Navigating portal hypertension: Unlocking safe passage to healthy pregnancy in EHPVO

作者：Akash Shukla, Ankita Singh, Akriti Saxena, Saurav Panda, Prajakta Mane, Nagma Khan, Sidharth Harindranath, Arun Vaidya, Michael Kuruthukulangara, Niranjan Mayadeo · 发表于：Liver International · 年份：2023 · DOI：10.1111/liv.15785 · 被引用次数：3 · 研究领域：Liver Disease and Transplantation、Appendicitis Diagnosis and Management、Abdominal vascular conditions and treatments

BACKGROUND AND AIMS: Pregnancy is associated with hyperdynamic circulatory state and increased risk of portal hypertension related complications in patients with extra-hepatic portal vein obstruction (EHPVO). We aim to study the impact of EHPVO on pregnancy-related outcomes with focus on subset of patients with UGIB (upper GI bleed). METHODS: Retrospective analysis of obstetric, maternal and neonatal outcomes of patients with EHPVO registered between January 2006 and December 2022. Forty-five patients were included. Forty-five healthy females with low-risk pregnancies formed the control group. RESULTS: Adverse obstetric and neonatal outcomes were comparable between EHPVO and control group (22% vs. 28.6%; p > .05; low birth weight/ small for gestational age 17.8% vs. 36%, p = .0918 and 14.2% vs. 10%, p = .5698 respectively). Adverse outcomes were similar in patients with and without history of UGIB (26.3% vs. 19.4%, p = .0814; 17.8% vs. 36%, p = .0918; 14.2% vs. 10%, p = .5698). There was no maternal mortality in both the groups. A total of 7% pregnancies in EHPVO patients were complicated by ascites. CONCLUSIONS: EHPVO pregnancies have successful obstetric and neonatal outcomes with adequate management of portal hypertension.