Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories

作者：Devin Razavi‐Shearer, Hannah Child, K. Razavi-Shearer, Alexis Voeller, Homie Razavi, Marı́a Buti, Frank Tacke, Norah A. Terrault, Stefan Zeuzem, Zaigham Abbas, Alessio Aghemo, Ulus Salih Akarca, Nasser Al Masri, Abdullah A. Alalwan, Marianne Alanko Blomé, Anna Jerkeman, Soo Aleman, Habiba Kamal, Abdullah Alghamdi, Majed Alghamdi, Saad Alghamdi, Waleed Al–Hamoudi, Elsayed Mostafa Ali, Abdulrahman Aljumah, I. Altraif, J. Amarsanaa, Tarik Asselah, Oidov Baatarkhuu, Adriana Babameto, Ziv Ben‐Ari, Thomas Berg, Mia J. Biondi, Wornei Silva Miranda Braga, Carlos Eduardo Brandão‐Mello, Robert S. Brown, Maurizia Rossana Brunetto, Joaquín Cabezas, Mariana Cardoso, Alexandra Martins, Henry Lik‐Yuen Chan, Hugo Cheinquer, C.-J. Chen, Hwai‐I Yang, Pei‐Jer Chen, Cheng‐Hung Chien, Wan‐Long Chuang, L. Cisneros Garza, B. Coco, Carla S. Coffin, Nicola Coppola, Markus Cornberg, Antonio Craxı̀, Javier Crespo, Liri Çuko, Victor de Lédinghen, A.‐S. Duberg, Ohad Etzion, Maria Lúcia Gomes Ferraz, Paulo Roberto Abrão Ferreira, Xavier Forns, Graham R. Foster, James Fung, Giovanni Battista Gaeta, Javier García‐Samaniego, J Genov, Liliana Gheorghe, Patrick Gholam, Robert G. Gish, Jeffrey S. Glenn, Saeed Hamid, Julian Hercun, Yao‐Chun Hsu, Chih-Chien Hu, Jee‐Fu Huang, Ramazan Idılman, Wasim Jafri, Naveed Z. Janjua, Deian Jelev, Jidong Jia, Martin Kåberg, Kelly Kaita, Jia‐Horng Kao, Aamir Khan, Do Young ‍Kim, Loreta A. Kondili, Martin Lagging, Pietro Lampertico, Pablo Lázaro, Jeffrey V. Lazarus, M.-H. Lee, Hwai‐I Yang, Young‐Suk Lim, Cirley Lobato, Guilherme Macedo, Rui Tato Marinho, Paul Marotta, Maria Cássia Mendes-Corrêa, Nahúm Méndez‐Sánchez, M.-C. Navas, Qing Ning, Necati Örmecı, Mauricio Orrego, Carla Osiowy, Calvin Q. Pan, Mário Guimarães Pessôa, Zahra Zahid Piracha, Corina Silvia Pop, Huma Qureshi, Giovanni Raimondo, Alnoor Ramji, Sofia Ribeiro, Cielo Ríos, Manuel Rodríguez, William Rosenberg, Dominique Roulot, Stephen Ryder, U. Saeed, Rifaat Safadi, Daniel Shouval, Faisal M. Sanai, J.F. Sánchez-Ávila, Teresa Santantonio, Christoph Sarrazin, Wai‐Kay Seto, Wai‐Kay Seto, Marieta Simonova, Junko Tanaka, Tammo Lambert Tergast, O. Tsendsuren, Cristina Valente, Juan Miguel Villalobos-Salcedo, Yasir Waheed, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Terry Cheuk‐Fung Yip, Vincent Wai‐Sun Wong, J.‐C. Wu, Hwai‐I Yang, Ming‐Lung Yu, Man‐Fung Yuen, Cihan Yurdaydın, Eli Zuckerman · 发表于：Journal of Hepatology · 年份：2023 · DOI：10.1016/j.jhep.2023.10.043 · 被引用次数：101 · 研究领域：Hepatitis B Virus Studies、Hepatitis Viruses Studies and Epidemiology、Hepatitis C virus research

BACKGROUND & AIMS: Hepatitis delta virus (HDV) is a satellite RNA virus that requires the hepatitis B virus (HBV) for assembly and propagation. Individuals infected with HDV progress to advanced liver disease faster than HBV-monoinfected individuals. Recent studies have estimated the global prevalence of anti-HDV antibodies among the HBV-infected population to be 5-15%. This study aimed to better understand HDV prevalence at the population level in 25 countries/territories. METHODS: We conducted a literature review to determine the prevalence of anti-HDV and HDV RNA in hepatitis B surface antigen (HBsAg)-positive individuals in 25 countries/territories. Virtual meetings were held with experts from each setting to discuss the findings and collect unpublished data. Data were weighted for patient segments and regional heterogeneity to estimate the prevalence in the HBV-infected population. The findings were then combined with The Polaris Observatory HBV data to estimate the anti-HDV and HDV RNA prevalence in each country/territory at the population level. RESULTS: After adjusting for geographical distribution, disease stage and special populations, the anti-HDV prevalence among the HBsAg+ population changed from the literature estimate in 19 countries. The highest anti-HDV prevalence was 60.1% in Mongolia. Once adjusted for the size of the HBsAg+ population and HDV RNA positivity rate, China had the highest absolute number of HDV RNA+ cases. CONCLUSIONS: We found substantially l...