Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study

作者：Kui Wang, Xianzheng Qin, Taojing Ran, Yundi Pan, Hong Yu, Jiawei Wang, Xian‐Da Zhang, Xiaonan Shen, Chenxiao Liu, Xinchen Lu, Yifei Chen, Yaya Bai, Yao Zhang, Chunhua Zhou, Duowu Zou · 发表于：Frontiers in Microbiology · 年份：2023 · DOI：10.3389/fmicb.2023.1290202 · 被引用次数：24 · 研究领域：Pancreatitis Pathology and Treatment、Gut microbiota and health、Genetic Associations and Epidemiology

Background: A number of recent observational studies have indicated a correlation between the constitution of gut microbiota and the incidence of pancreatitis. Notwithstanding, observational studies are unreliable for inferring causality because of their susceptibility to confounding, bias, and reverse causality, the causal relationship between specific gut microbiota and pancreatitis is still unclear. Therefore, our study aimed to investigate the causal relationship between gut microbiota and four types of pancreatitis. Methods: An investigative undertaking encompassing a genome-wide association study (GWAS) comprising 18,340 participants was undertaken with the aim of discerning genetic instrumental variables that exhibit associations with gut microbiota, The aggregated statistical data pertaining to acute pancreatitis (AP), alcohol-induced AP (AAP), chronic pancreatitis (CP), and alcohol-induced CP (ACP) were acquired from the FinnGen Consortium. The two-sample bidirectional Mendelian randomization (MR) approach was utilized. Utilizing the Inverse-Variance Weighted (IVW) technique as the cornerstone of our primary analysis. The Bonferroni analysis was used to correct for multiple testing, In addition, a number of sensitivity analysis methodologies, comprising the MR-Egger intercept test, the Cochran's Q test, MR polymorphism residual and outlier (MR-PRESSO) test, and the leave-one-out test, were performed to evaluate the robustness of our findings. Results: = 0.008) has a ...