Copy number variants of ERG11: mechanism of azole resistance in Candida parapsilosis

作者：Yating Ning, Rongchen Dai, Li Zhang, Yingchun Xu, Meng Xiao · 发表于：The Lancet Microbe · 年份：2023 · DOI：10.1016/s2666-5247(23)00294-x · 被引用次数：25 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Infectious Diseases and Mycology

Faranz Daneshnia and colleagues1Daneshnia F de Almeida Júnior, JN Ilkit M et al.Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.Lancet Microbe. 2023; 4: e470-e480Summary Full Text Full Text PDF PubMed Scopus (0) Google Scholar reviewed challenges posed by emerging worldwide azole resistance in Candida parapsilosis and the resistance-related biological features of this pathogen. As discussed in the Review, the resistance caused by an increased copy number of ERG11 that has been observed in other Candida species is of global concern (eg, C albicans1Daneshnia F de Almeida Júnior, JN Ilkit M et al.Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap.Lancet Microbe. 2023; 4: e470-e480Summary Full Text Full Text PDF PubMed Scopus (0) Google Scholar, 2Berman J Krysan DJ Drug resistance and tolerance in fungi.Nat Rev Microbiol. 2020; 18: 319-331Crossref PubMed Scopus (241) Google Scholar, 3Gow NAR Johnson C Berman J et al.The importance of antimicrobial resistance in medical mycology.Nat Commun. 2022; 135352Crossref PubMed Scopus (41) Google Scholar and C auris4Muñoz JF Gade L Chow NA et al.Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species.Nat Commun. 2018; 95346Crossref Scopus (238) Google Scholar), yet the resistance mechanism has not been identified in C parapsilosis. Our work adds to the relevant ...