The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

作者：Ruoxue Bai, Yaotao Guo, Wei Liu, Yajuan Song, Zhou Yu, Xianjie Ma · 发表于：Biomolecules · 年份：2023 · DOI：10.3390/biom13121702 · 被引用次数：44 · 研究领域：Wnt/β-catenin signaling in development and cancer、Wound Healing and Treatments、Skin and Cellular Biology Research

The WNT signaling pathway plays a critical role in a variety of biological processes, including development, adult tissue homeostasis maintenance, and stem cell regulation. Variations in skin conditions can influence the expression of the WNT signaling pathway. In light of the above, a deeper understanding of the specific mechanisms of the WNT signaling pathway in different physiological and pathological states of the skin holds the potential to significantly advance clinical treatments of skin-related diseases. In this review, we present a comprehensive analysis of the molecular and cellular mechanisms of the WNT signaling pathway in skin development, wound healing, and mechanical stretching. Our review sheds new light on the crucial role of the WNT signaling pathway in the regulation of skin physiology and pathology.