Enhanced Antibacterial and Wound Healing Using a Metal‐Organic Cluster Inspired by Artificial Photosynthesis

作者：Long Zhu, Antian Huo, Yangqian Sun, Yanzhao Chen, Chongjiang Cao, Yueqin Zheng, Weiwei Guo · 发表于：Advanced Healthcare Materials · 年份：2023 · DOI：10.1002/adhm.202302087 · 被引用次数：5 · 研究领域：Advanced Photocatalysis Techniques、Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics

Abstract Bacterial infection poses a constant threat to human health. It is crucial to develop cost‐effective and multifunctional solutions to combat bacteria. In this study, inspiration has been taken from artificial photosynthesis and a hydrogel containing a photocatalytic metal‐organic cluster (MOC) has been creatively formulated for wound healing and antibacterial purposes. Complete photocatalytic cycles have been achieved by combining the oxidative Ti‐center and the reductive Cu‐center, in which reactive oxygen species ( 1 O 2 and ·OH) have been generated. The MOC has the capability to eliminate Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) at a concentration of 40 µg mL −1 . In addition, the hydrogel formulation (H‐MOC) has been applied to wounds infected with S. aureus , resulting in improved healing efficiency. This work presents an innovative approach to utilizing photocatalytic biomaterials as non‐antibiotic medications.