Association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population

作者：Jiaqi Chen, Kangxiang Wu, Yi‐Ying Lin, Ming-Yuan Huang, Shang-He Xie · 发表于：Cardiovascular Diabetology · 年份：2023 · DOI：10.1186/s12933-023-02054-5 · 被引用次数：145 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Function and Risk Factors、Hyperglycemia and glycemic control in critically ill and hospitalized patients

OBJECTIVE: The Triglyceride-glucose (TyG) index, a novel indicator of insulin resistance, has been associated with mortality from coronary artery diseases, ischemic stroke, and heart failure. In recent years, much emphasis has been placed on the relationship between the TyG index and mortality in the general population. However, the impact of age on the association between TyG and all-cause and cardiovascular mortality remains controversial. This study investigated the link between the TyG index and all-cause and cardiovascular mortality, emphasizing differences between older and non-older populations. METHODS: Data from the National Health and Nutrition Examination Survey (2009-2018), encompassing 20,194 participants, were analyzed. The baseline TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate Cox proportional hazards regression models with restricted cubic splines and trend tests were employed to explore the association between the TyG index and all-cause and cardiovascular mortality, with emphasis on age-specific analysis. Subgroup analysis was conducted to examine whether the TyG index's association with mortality varied across different subgroups. Additionally, receiver operating characteristic curves were used to compare the predictive ability of the TyG index with the homeostasis model assessment of insulin resistance (HOMA-IR) for all-cause and cardiovascular mortality. RESULTS: Over a median follow-up period of ...