Digital Phenotyping for Mood Disorders: Methodology-Oriented Pilot Feasibility Study

作者：Scott Breitinger, Manuel Gardea‐Resendez, Carsten Langholm, Ashley Xiong, Joseph Laivell, Cynthia Stoppel, Laura Harper, Rama Volety, Alex J Walker, Ryan D’Mello, Andrew Jin Soo Byun, Peter P. Zandi, Fernando S. Goes, Mark A. Frye, John Torous · 发表于：Journal of Medical Internet Research · 年份：2023 · DOI：10.2196/47006 · 被引用次数：9 · 研究领域：Digital Mental Health Interventions、Mobile Health and mHealth Applications、Bipolar Disorder and Treatment

BACKGROUND: In the burgeoning area of clinical digital phenotyping research, there is a dearth of literature that details methodology, including the key challenges and dilemmas in developing and implementing a successful architecture for technological infrastructure, patient engagement, longitudinal study participation, and successful reporting and analysis of diverse passive and active digital data streams. OBJECTIVE: This article provides a narrative rationale for our study design in the context of the current evidence base and best practices, with an emphasis on our initial lessons learned from the implementation challenges and successes of this digital phenotyping study. METHODS: We describe the design and implementation approach for a digital phenotyping pilot feasibility study with attention to synthesizing key literature and the reasoning for pragmatic adaptations in implementing a multisite study encompassing distinct geographic and population settings. This methodology was used to recruit patients as study participants with a clinician-validated diagnostic history of unipolar depression, bipolar I disorder, or bipolar II disorder, or healthy controls in 2 geographically distinct health care systems for a longitudinal digital phenotyping study of mood disorders. RESULTS: We describe the feasibility of a multisite digital phenotyping pilot study for patients with mood disorders in terms of passively and actively collected phenotyping data quality and enrollment of pati...