Stem Cell Therapy: A Possible Role in the Treatment of Patients with Chronic Limb-Threatening Ischemia?

作者：A. Olson, Bright Benfor, Eric K. Peden · 发表于：Methodist DeBakey Cardiovascular Journal · 年份：2023 · DOI：10.14797/mdcvj.1291 · 被引用次数：4 · 研究领域：Peripheral Artery Disease Management、Biomedical Ethics and Regulation、Angiogenesis and VEGF in Cancer

Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral arterial disease that portends high morbidity and mortality. Patients may undergo various endovascular or open procedures with the goal of limb salvage. No-option CLTI patients represent a vulnerable population for whom conventional options have been exhausted, or anatomy precludes any attempts at revascularization, often resulting in amputation. Stem cell therapy is under investigation for these no-option CLTI patients. Regardless of revascularization technique, these patients are clinically challenging and require multidisciplinary efforts to achieve the best outcomes. Here we present a patient with unfavorable anatomy who underwent stem cell therapy injection for a nonhealing right first toe wound, and we include points to remember when considering stem cell treatment in patients with CLTI.