Gelatin-Based Injectable Hydrogels Loaded with Copper Ion Cross-linked Tannic Acid Nanoparticles for Irregular Wound Closure Repair

作者：Yuanhua Zhang, Rongheng Chen, Li He, Xiaofei Wang, Dengjiang Wu, Yulin Lin, Mao Ye, Zhaoyin Zhu, Zhigang Chen, Yingping Jiang, Weijian Chen · 发表于：ACS Applied Nano Materials · 年份：2023 · DOI：10.1021/acsanm.3c03963 · 被引用次数：26 · 研究领域：Wound Healing and Treatments、Surgical Sutures and Adhesives、Pressure Ulcer Prevention and Management

It is often difficult to close and repair irregular wounds such as gums with traditional dressings that have a fixed shape, while injectable hydrogels that can be molded in situ offer tremendous advantages in treating complex, large wounds and can better seal or fill a variety of irregular wounds. While the majority of injectable hydrogels developed in current research have poor mechanical properties and biocompatibility and obstacles to clinical applications, this paper reports an injectable hydrogel that can be molded in situ with appropriate mechanical properties, excellent biocompatibility, and antibacterial activity. Under UV irradiation, a methacrylate-gelatin/poly(vinyl alcohol) loaded with copper ion cross-linked tannic acid nanoparticle (GelMA/PVA-TA/Cu 2+ NPs) precursor solution could rapidly gel within 45 s and adhere stably to the wound tissue by topological adhesion and hydrogen bonding. Through hydrogen bonding and physical entanglement, TA/Cu 2+ NPs are anchored in the GelMA/PVA interpenetrating network to form the GelMA/PVA-TA/Cu 2+ NPs composite hydrogel. This injectable hydrogel, which can quickly achieve photocurable in situ molding, can not only achieve closure and repair of irregular wounds but also has appropriate swelling characteristics, absorbing tissue exudate and blocking bacteria, while providing a good moist environment for wounds and continuously promoting wound healing. Cytotoxicity tests and wound healing experiments have shown that GelMA/PVA-T...