Age at menopause is inversely related to the prevalence of common gynecologic cancers: a study based on NHANES

作者：Guangdong Cheng, Mengmeng Wang, Hao Sun, Jingjiang Lai, Yukun Feng, Hongjin Liu, Yuwang Shang, Yuan Zhao, Bingli Zuo, Youhua Lu · 发表于：Frontiers in Endocrinology · 年份：2023 · DOI：10.3389/fendo.2023.1218045 · 被引用次数：10 · 研究领域：Endometrial and Cervical Cancer Treatments、Menopause: Health Impacts and Treatments、Cancer Risks and Factors

Background: The fluctuation or even loss of estrogen level caused by menopause in women, and most gynecological cancers often occur before and after menopause, so the age of menopause may be related to the occurrence of gynecological cancer. Aim: To investigate whether the age at menopause is independently associated with the incidence of gynecological cancers and to analyze the possible influencing factors. Methods: We selected the NHANES public database to conduct the study, and by excluding relevant influencing factors, we finally included 5706 NHANES participants who had full data on age at menopause and the occurrence of gynecologic cancers to analyze the relationship between the amount of age at menopause and gynecologic cancers based on univariate or multifactorial logistic regression analysis. Further, the relationship between age at menopause and the prevalence of different gynecologic cancers was investigated, and changes in the prevalence of different gynecologic cancers by age at menopause subgroups were observed. Finally, other relevant factors affecting the prevalence of gynecologic cancers were further investigated by subgroup analysis as well as subcluster analysis. Results: Univariate logistic regression analysis between age at menopause and gynecologic tumor prevalence revealed a negative association between age at menopause and the prevalence of common gynecologic cancers ovarian and cervical cancer, and after adjusting for the effects of covariates, a high...