Cerebrospinal fluid oligoclonal bands in Chinese patients with multiple sclerosis: the prevalence and its association with clinical features

作者：Xiang Zhang, Hong-Jun Hao, Tao Jin, Wei Qiu, Huan Yang, Qun Xue, Jian Yin, Ziyan Shi, Hai Yu, Xiaopei Ji, Xiaobo Sun, Qiuming Zeng, Xiaoni Liu, Jingguo Wang, Huining Li, Huining Li, Xiao-Yan He, Jing Yang, Yarong Li, Shuangshuang Liu, Alexander Yuk Lun Lau, Feng Gao, Shimin Hu, Shuguang Chu, Ding Ding, Hongyu Zhou, Haifeng Li, Haifeng Li, Xiangjun Chen · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1280020 · 被引用次数：10 · 研究领域：Multiple Sclerosis Research Studies、Systemic Lupus Erythematosus Research、Cerebrospinal fluid and hydrocephalus

Background: Cerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance in Chinese MS patients, especially in the virtue of common standard operation procedure (SOP). Methods: With a consensus SOP and the same isoelectric focusing system, we conducted a nationwide multi-center study on OCB status in consecutively, and recruited 483 MS patients and 880 non-MS patients, including neuro-inflammatory diseases (NID, n = 595) and non-inflammatory neurological diseases (NIND, n=285). Using a standardized case report form (CRF) to collect the clinical, radiological, immunological, and CSF data, we explored the association of CSF-OCB positivity with patient characters and the diagnostic performance of CSF-OCB in Chinese MS patients. Prospective source data collection, and retrospective data acquisition and statistical data analysis were used. Findings: 369 (76.4%) MS patients were OCB-positive, while 109 NID patients (18.3%) and 6 NIND patients (2.1%) were OCB-positive, respectively. Time from symptom onset to diagnosis was significantly shorter in OCB-positive than that in OCB-negative MS patients (13.2 vs 23.7 months, P=0.020). The prevalence of CSF-OCB in Chinese MS patients was significantly higher in high-latitude regions (41°-50°N)(P=0.016), and at high altitudes (>1000m)(P=0.025). The diagnostic performance of CSF-OCB differentiating M...