Association of inflammatory indicators with intensive care unit mortality in critically ill patients with coronary heart disease

作者：Yuan Cheng, Yang Chen, Meng-Xia Mao, Ruixuan Wang, Jun Zhu, Qing He · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1295377 · 被引用次数：19 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Sepsis Diagnosis and Treatment、Inflammation biomarkers and pathways

Objective: Coronary heart disease (CHD) is one of the major cardiovascular diseases, a common chronic disease in the elderly and a major cause of disability and death in the world. Currently, intensive care unit (ICU) patients have a high probability of concomitant coronary artery disease, and the mortality of this category of patients in the ICU is receiving increasing attention. Therefore, the aim of this study was to verify whether the composite inflammatory indicators are significantly associated with ICU mortality in ICU patients with CHD and to develop a simple personalized prediction model. Method: 7115 patients from the Multi-Parameter Intelligent Monitoring in Intensive Care Database IV were randomly assigned to the training cohort (n = 5692) and internal validation cohort (n = 1423), and 701 patients from the eICU Collaborative Research Database served as the external validation cohort. The association between various inflammatory indicators and ICU mortality was determined by multivariate Logistic regression analysis and Cox proportional hazards model. Subsequently, a novel predictive model for mortality in ICU patients with CHD was developed in the training cohort and performance was evaluated in the internal and external validation cohorts. Results: Various inflammatory indicators were demonstrated to be significantly associated with ICU mortality, 30-day ICU mortality, and 90-day ICU mortality in ICU patients with CHD by Logistic regression analysis and Cox prop...