Near-Infrared Fluoride Sensing Nano-Optodes and Distance-Based Hydrogels Containing Aluminum-Phthalocyanine

作者：Lanfei Wang, Ye Zhang, Liyuan Wang, Yu Cheng, Dajing Yuan, Jingying Zhai, Xiaojiang Xie · 发表于：ACS Sensors · 年份：2023 · DOI：10.1021/acssensors.3c01848 · 被引用次数：18 · 研究领域：Analytical Chemistry and Sensors、Fluoride Effects and Removal、Molecular Sensors and Ion Detection

Fluoride ions are highly relevant in environmental and biological sciences, and there is a very limited number of established fluoride chemical sensors. Previous fluoride-selective optodes were demonstrated with metal-porphyrin as the ionophore and required a chromoionophore for optical signal transduction. We demonstrate here novel optical fluoride sensing with nano-optodes containing an aluminum-phthalocyanine complex (AlClPc) as the single active sensing component, simplifying the conventional ion-selective optodes approach. The fluoride nano-optodes were interrogated in the absorbance and fluorescence modes in the near-infrared region, with absorption around 725 nm and emission peaks at 720 and 800 nm, respectively. The nano-optodes exhibited a lower detection limit around 0.1 μM and good selectivity over a range of common anions including ClO 4 –, Cl –, Br –, I –, SO 4 2–, NO 3 –, and AcO – . Furthermore, the nano-optodes were physically entrapped in agarose hydrogels to allow distance-based point-of-care testing (POCT) applications. The 3D networks of the agarose hydrogel were able to filter off large particulates in the samples without stopping fluoride ions to reach the nano-optodes. The fluoride concentrations in real samples including river water, mineral water, and groundwater were successfully determined with the distance-based sensing hydrogel, and the results agreed well with those from commercial fluoride electrodes. Therefore, the results in this work lay the ...