Does endometrial compaction before embryo transfer affect pregnancy outcomes? a systematic review and meta-analysis

作者：Xiaotong Chen, Zhen‐Gao Sun, Jing‐Yan Song · 发表于：Frontiers in Endocrinology · 年份：2023 · DOI：10.3389/fendo.2023.1264608 · 被引用次数：10 · 研究领域：Ovarian function and disorders、Reproductive System and Pregnancy、Ectopic Pregnancy Diagnosis and Management

Objective There is no clear evidence of clinical significance of endometrial compaction, which can be measured by a reduction in endometrial thickness (EMT) during the follicular-luteal transition before the day of embryo transfer. In this study, we aim to determine whether endometrial compaction has an effect on in vitro fertilization (IVF) success. Method(s) We searched PubMed, Cochrane, Embase, and Web of Science electronic databases for studies published in English up to March 2023. Heterogeneity between studies was assessed using the I 2 statistic. The random effects model and fixed effects model was used to pool the risk ratio (RR) with a corresponding 95% confidence interval (CI). A subgroup analysis was performed based on different methods of ultrasonic measurement and different endometrial compaction rates (ECR). Stata 17.0 software was used for meta-analysis. Pregnancy outcomes, which included clinical pregnancy rate, ongoing pregnancy rate, live birth rate, and spontaneous abortion rate, were evaluated. Result(s) In this study, 18 cohort studies were included, involving 16,164 embryo transfer cycles. Pooled results indicated that there was no significant difference between the endometrial compaction group and the non-compaction group in terms of clinical pregnancy rate (RR [95% CI]=0.98 [0.90,1.08]; I 2 = 69.76%), ongoing pregnancy rate (RR [95% CI]=1.18 [0.95,1.47]; I 2 = 78.77%), live birth rate (RR [95% CI]= 0.97 [0.92,1.02]; I 2 = 0.00%) or spontaneous abortion...