Acupuncture vs Massage for Pain in Patients Living With Advanced Cancer

作者：Andrew S. Epstein, Kevin T. Liou, Sally A.D. Romero, Raymond E. Baser, Greta Wong, Han Xiao, Zunli Mo, Desiree Walker, Jodi MacLeod, Qing Li, Margaret Barton‐Burke, Gary Deng, Katherine S. Panageas, John T. Farrar, Jun J. Mao · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.42482 · 被引用次数：69 · 研究领域：Acupuncture Treatment Research Studies、Complementary and Alternative Medicine Studies、Cancer survivorship and care

Importance: Pain is challenging for patients with advanced cancer. While recent guidelines recommend acupuncture and massage for cancer pain, their comparative effectiveness is unknown. Objective: To compare the effects of acupuncture and massage on musculoskeletal pain among patients with advanced cancer. Design, Setting, and Participants: A multicenter pragmatic randomized clinical trial was conducted at US cancer care centers consisting of a northeastern comprehensive cancer center and a southeastern cancer institute from September 19, 2019, through February 23, 2022. The principal investigator and study statisticians were blinded to treatment assignments. The duration of follow-up was 26 weeks. Intention-to-treat analyses were performed (linear mixed models). Participants included patients with advanced cancer with moderate to severe pain and clinician-estimated life expectancy of 6 months or more. Patient recruitment strategy was multipronged (eg, patient database queries, mailings, referrals, community outreach). Eligible patients had English or Spanish as their first language, were older than 18 years, and had a Karnofsky score greater than or equal to 60 (range, 0-100; higher scores indicating less functional impairment). Interventions: Weekly acupuncture or massage for 10 weeks with monthly booster sessions up to 26 weeks. Main Outcomes and Measures: The primary end point was the change in worst pain intensity score from baseline to 26 weeks. The secondary outcomes i...