Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states

作者：Kaiyuan Ji, Junmin Zhong, Long Cui, Xiaodi Wang, Lina Chen, Bolun Wen, Fan Yang, Wenfeng Deng, Xiuyu Pan, Lele Wang, Junjie Bao, Yunshan Chen, Huishu Liu · 发表于：Physiological Genomics · 年份：2023 · DOI：10.1152/physiolgenomics.00067.2023 · 被引用次数：20 · 研究领域：Reproductive System and Pregnancy、Pregnancy and preeclampsia studies、Preterm Birth and Chorioamnionitis

Using single-cell RNA sequencing and spatial transcriptomics, the myometrium was examined at the single-cell level during pregnancy. We identified spatially distinct cell populations and observed alterations in smooth muscle cells and increased M2 macrophages in term pregnant women. These findings offer unprecedented insights into myometrial remodeling and the anti-inflammatory response during pregnancy. The study advances our understanding of pregnancy-related myometrial changes.