Iron-catalyzed asymmetric Csp 3 –H/Csp 3 –H coupling: improving the chirality induction by mechanochemical liquid-assisted grinding

作者：Ping Ying, Ying Tao, Hong Chen, Keyu Xiang, Weike Su, Haijiao Xie, Jingbo Yu · 发表于：Organic Chemistry Frontiers · 年份：2023 · DOI：10.1039/d3qo01467c · 被引用次数：21 · 研究领域：Alkaloids: synthesis and pharmacology、Axial and Atropisomeric Chirality Synthesis、Microbial Natural Products and Biosynthesis

A mechanochemical iron-catalyzed asymmetric oxidative coupling between glycines and β-ketoesters has been disclosed, utilizing t -BuOH to improve the enantioselectivity and stabilize the iminium intermediate via intensified hydrogen bond interactions.