Mendelian-randomization study reveals causal relationships between nitrogen dioxide and gut microbiota

作者：Huajie Yang, Peng Shi, Mingzheng Li, Lingxu Kong, Shuailing Liu, Liujiangshan Jiang, Jing Yang, Bin Xu, Tianyao Yang, Shuhua Xi, Wei Liu · 发表于：Ecotoxicology and Environmental Safety · 年份：2023 · DOI：10.1016/j.ecoenv.2023.115660 · 被引用次数：14 · 研究领域：Gut microbiota and health、Nutritional Studies and Diet、Health disparities and outcomes

Exposure to nitrogen dioxide might potentially change the makeup and operation of gut microbes. Nitrogen dioxide data was procured from the IEU Open GWAS (N = 456 380). Subsequently, a two-sample Mendelian randomization study was executed, utilizing summary statistics of gut microbiota sourced from the most expansive available genome-wide association study meta-analysis, conducted by the MiBioGen consortium (N = 13 266). The causal relationship between nitrogen dioxide and gut microbiota was determined using inverse variance weighted, maximum likelihood, MR-Egger, Weighted Median, Weighted Model, Mendelian randomization pleiotropy residual sum and outlier, and constrained maximum likelihood and model averaging and Bayesian information criterion. The level of heterogeneity of instrumental variables was quantified by utilizing Cochran’s Q statistic. The colocalization analysis was used to examine whether nitrogen dioxide and the identified gut microbiota shared casual variants. Inverse variance weighted estimate suggested that nitrogen dioxide was causally associated with Akkermansia (β = −1.088, 95% CI: −1.909 to −0.267, P = 0.009). In addition, nitrogen dioxide presented a potential association with Bacteroides (β = −0.938, 95% CI: −1.592 to −0.284, P = 0.005), Barnesiella (β = −0.797, 95% CI: −1.538 to −0.055, P = 0.035), Coprococcus 3 (β = 1.108, 95% CI: 0.048–2.167, P = 0.040), Eubacterium hallii group (E. hallii) (β = 0.776, 95% CI: 0.090–1.463, P = 0.027), Holdemania (β ...