Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

作者：Lina Liu, Yihui Chen, Bei Chen, Min Xu, Shuji Liu, Yongchang Su, Kun Qiao, Zhiyu Liu · 发表于：Preprints.org · 年份：2023 · DOI：10.20944/preprints202311.0167.v1 · 被引用次数：8 · 研究领域：Fatty Acid Research and Health

Hyperlipidemia (HLP) is a metabolic disease caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing yearly. In addition, the current clinical use of lipid-lowering drugs has significant ameliorating effects on lipid levels but these actions are accompanied by certain side effects. However, bioactive marine substances have been verified to have various physiological activities such as hypoglycemic, antioxidant, antithrombotic, and effects on blood pressure. Therefore, marine biological sources of hypolipidemic active substances have attracted much attention. Moreover, some of the identified active substances have been found to induce hypolipidemia by inhibiting cholesterol synthesis and absorption, or by improving the composition of intestinal microorganisms. This article introduces the sources and classification of marine-derived hypolipidemic active substances, and describes current progress in research on the main mechanism of the hypolipidemic activity of these substances.