All-optical interrogation of brain-wide activity in freely swimming larval zebrafish

作者：Yuming Chai, Kexin Qi, Yubin Wu, Daguang Li, Guodong Tan, Yuqi Guo, Jun Chu, Mu Yu, C.-K. James Shen, Quan Wen · 发表于：iScience · 年份：2023 · DOI：10.1016/j.isci.2023.108385 · 被引用次数：13 · 研究领域：Zebrafish Biomedical Research Applications、Photoreceptor and optogenetics research、Retinal Development and Disorders

selective optogenetic stimulation of different regions of the brain. By demonstrating that selective light activation of the midbrain regions in larval zebrafish could reliably trigger biased turning behavior and changes of brain-wide neural activity, we present a valuable tool for investigating the causal relationship between distributed neural circuit dynamics and naturalistic behavior.