Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors

作者：Xiaoying Gu, Siyuan Wang, Wanying Zhang, Caihong Li, Li Guo, Zai Wang, Haibo Li, Hui Zhang, Yuhan Zhou, Weijian Liang, Hui Li, Yan Liu, Yeming Wang, Lixue Huang, Tao Dong, Dingyu Zhang, Catherine C. L. Wong, Bin Cao · 发表于：EBioMedicine · 年份：2023 · DOI：10.1016/j.ebiom.2023.104851 · 被引用次数：66 · 研究领域：Long-Term Effects of COVID-19、COVID-19 Clinical Research Studies、Neuroinflammation and Neurodegeneration Mechanisms

BACKGROUND: As a debilitating condition that can impact a whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever. However, mechanisms of long COVID are not clearly understood, and underlying biomarkers that can affect the long-term consequences of COVID-19 are paramount to be identified. METHODS: Participants for the current study were from a cohort study of COVID-19 survivors discharged from hospital between Jan 7, and May 29, 2020. We profiled the proteomic of plasma samples from hospitalised COVID-19 survivors at 6-month, 1-year, and 2-year after symptom onset and age and sex matched healthy controls. Fold-change of >2 or <0.5, and false-discovery rate adjusted P value of 0.05 were used to filter differentially expressed proteins (DEPs). In-genuity pathway analysis was performed to explore the down-stream effects in the dataset of significantly up- or down-regulated proteins. Proteins were integrated with long-term consequences of COVID-19 survivors to explore potential biomarkers of long COVID. FINDINGS: The proteomic of 709 plasma samples from 181 COVID-19 survivors and 181 matched healthy controls was profiled. In both COVID-19 and control group, 114 (63%) were male. The results indicated four major recovery modes of biological processes. Pathways related to cell-matrix interactions and cytoskeletal remodeling and hypertrophic cardiomyopathy and dilated cardiomyopathy pathways recovered relatively earlier which was ...