Association between cerebrovascular disease and perioperative neurocognitive disorders: a retrospective cohort study

作者：Lan Feng, Yuanhui Liu, Pengfei Li, Hengjun Wan, Xiren Deng, Tingting Wang, Hong Fu, Xiaoxia Duan · 发表于：International Journal of Surgery · 年份：2023 · DOI：10.1097/js9.0000000000000842 · 被引用次数：14 · 研究领域：Intensive Care Unit Cognitive Disorders、Enhanced Recovery After Surgery、Cardiac, Anesthesia and Surgical Outcomes

BACKGROUND: Previous studies have shown that patients with cerebrovascular disease (CVD) have a significantly increased risk of cognitive decline or dementia; however, the association between preoperative CVD and perioperative neurocognitive disorders (PNDs) remains unclear. This study aimed to explore the correlation between preoperative CVD and PNDs, as well as combine logistic regression and receiver operating characteristic (ROC) curves to construct a clinical prediction PND model. MATERIALS AND METHODS: This retrospective cohort study evaluated 13 899 surgical patients of a large-scale comprehensive hospital between January 2021 and January 2022 to explore the association between preoperative CVD and PNDs, with follow-up to monitor postoperative survival until 28 February 2023, unless the patient died. The study participants comprised all inpatients from the Bone and Joint Surgery, Spine Surgery, Urology, Hepatobiliary Surgery, Gastrointestinal Surgery, and Thoracic Surgery departments. Patients were classified into two groups: the CVD group with a confirmed diagnosis and the noncerebrovascular disease group. The incidence of PNDs was measured, and potential associations between patient demographic information, preoperative comorbidities, and CVD, as well as the correlation between preoperative CVD and PNDs, were investigated by multivariate logistic regression analysis. Next, the authors constructed a clinical prediction PND model by drawing the ROC curve. The postopera...