Recent advances and prospects of metal–organic frameworks in cancer therapies

作者：Zhiying Luo, Yu Sheng, Chenyi Jiang, Ying Pan, Xiaoxiong Wang, Alireza Nezamzadeh‐Ejhieh, Jie Ouyang, Chengyu Lu, Jianqiang Liu · 发表于：Dalton Transactions · 年份：2023 · DOI：10.1039/d3dt02543h · 被引用次数：39 · 研究领域：Nanoplatforms for cancer theranostics、Metal-Organic Frameworks: Synthesis and Applications、Advanced Nanomaterials in Catalysis

Metal-organic frameworks (MOFs) have been broadly applied in biomedical and other fields. MOFs have high porosity, a large comparative area, and good biostability and have attracted significant attention, especially in cancer therapies. This paper presents the latest applications of MOFs in chemodynamic therapy (CDT), sonodynamic therapy (SDT), photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy (IT), and combination therapy for breast cancer. A combination therapy is the combination of two different treatment modalities, such as CDT and PDT combination therapy, and is considered more effective than separate therapies. Herein, we have also discussed the advantages and disadvantages of combination therapy in the treatment of breast cancer. This paper aims to illustrate the potential of MOFs in new cancer therapeutic approaches, discuss their potential advantages, and provide some reflections on the latest research results.