Sex-modified association between grip strength and mild cognitive impairment: a cross-sectional and follow-up study in rural China

作者：Wenjing Feng, Qian Chen, Mingfeng Ma, Jiahui Xu, Hui Guo, Wei Yuan, Ruixue Li, Hanshu Gao, Cuiying Gu, Yanan Ma, Zhaoqing Sun, Nan Tuo, Liqiang Zheng · 发表于：BMC Geriatrics · 年份：2023 · DOI：10.1186/s12877-023-04376-1 · 被引用次数：16 · 研究领域：Nutrition and Health in Aging、Dementia and Cognitive Impairment Research、Nutritional Studies and Diet

Abstract Background The sex difference in the association between grip strength and mild cognitive impairment (MCI) remains controversial and unclear. Methods This is a part of a chronic disease cohort study conducted in rural areas, Fuxin, Liaoning Province, China. At the baseline survey, a total of 2633 participants aged 35- 85 were included in the cross-sectional study. Handgrip strength (HGS, kg) was measured by a dynamometer (Jamar +). MCI were assessed using the Chinese version of the Montreal Cognitive Assessment-Basic (MOCA-BC). Then, a total of 1667 cognitively normal individuals (NCs) were planed to follow up and to assess the incident MCI after two years. We used logistic regression to examine the association between HGS (as a continuous variable and quintiles) and MCI and analyzed the interaction between sex and HGS on MCI. Models stratified by sex were adjusted for demographic information (age, ethnicity, education, marital status, income, physical labor level), modifiable risk factors (body mass index, smoking, drinking) and disease history (hypertension, diabetes, dyslipidemia and coronary heart disease). Baseline MOCA-BC scores were additionally adjusted in the longitudinal study. Results In the cross-sectional study, participants were on average 56.6 ± 9.8 years, and 1713 (65.1%) were females. In the cohort study, 743 individuals were followed up with an average age of 55.9 ± 9.6 years, which included 530 (71.3%) females. The cumulative incidence of MCI over ...