The inflammatory response of human pancreatic cancer samples compared to normal controls

作者：Kathryn J. Brayer, Joshua Anspach Hanson, Shashank Reddy Cingam, C. Gaspar Martinez, Scott A. Ness, Ian Rabinowitz · 发表于：PLoS ONE · 年份：2023 · DOI：10.1371/journal.pone.0284232 · 被引用次数：14 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Genomics and Diagnostics、Gut microbiota and health

Pancreatic ductal adenocarcinoma (PDAC) is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options. PDAC growth has been linked to alterations in the pancreas microbiome, which could include the presence of the fungus Malassezia. We used RNA-sequencing to compare 14 matched tumor and normal (tumor adjacent) pancreatic cancer samples and found Malassezia RNA in both the PDAC and normal tissues. Although the presence of Malassezia was not correlated with tumor growth, a set of immune- and inflammatory-related genes were up-regulated in the PDAC compared to the normal samples, suggesting that they are involved in tumor progression. Gene set enrichment analysis suggests that activation of the complement cascade pathway and inflammation could be involved in pro PDAC growth.