Peroxynitrite-Scavenging Organosilica Nanomedicines for Light-Controllable NO Release and Precision On-Demand Glaucoma Therapy

作者：Maomao Song, Liping Li, Jiamin Liu, Yanting Gao, Mengwei Li, Liming Zhou, Bo Qin, Ajun Xiang, Xinghuai Sun, Wenpei Fan, Yuan Lei, Xiaoyuan Chen · 发表于：ACS Nano · 年份：2023 · DOI：10.1021/acsnano.3c02685 · 被引用次数：17 · 研究领域：Glaucoma and retinal disorders、Corneal Surgery and Treatments、Corneal surgery and disorders

Nitric oxide (NO) is a promising approach for treating ocular hypertension and glaucoma. However, its clinical application is limited by its uncontrollable release and the unwanted overproduction of peroxynitrite. Herein, a denitrifying hollow mesoporous organosilica nanoparticle (HMMN) with framework cohybridization is first constructed to encapsulate S -nitroso- N -acetyl- d, l -penicillamine (SNAP) to produce SNAP@HMMN with dual capacities of selective peroxynitrite removal and controllable NO release. Featuring a large corneal permeability, the well-designed SNAP@HMMN can achieve trans-corneal delivery to reach the target trabecular meshwork (TM)/Schlemm’s canal (SC) site. Upon light irradiation, the intraocular pressure (IOP) is appropriately lowered in an adjustable and long-lasting manner while the outflow tissues are protected from nitrative damage, which is expected to realize precision on-demand glaucoma therapy with little biosafety concern, promising significant clinical translational potential.