Age-related differences in clinical and laboratory characteristics of childhood-onset systemic lupus erythematosus: Pre-puberal-onset SLE is prone to delayed diagnosis

作者：Shipeng Li, Yuan Xue, Weiying Kuang, Jianghong Deng, Junmei Zhang, Xiaohua Tan, Chao Li, Caifeng Li, Caifeng Li, Caifeng Li · 发表于：Lupus · 年份：2023 · DOI：10.1177/09612033231212522 · 被引用次数：11 · 研究领域：Systemic Lupus Erythematosus Research、Cytomegalovirus and herpesvirus research、Rheumatoid Arthritis Research and Therapies

Objective This study aimed to analyze age-specific characteristics of childhood-onset systemic lupus erythematosus (cSLE) at a health center in China. Methods The children with SLE were grouped based on age at disease-onset: pre-pubertal (≤7 years), peri-pubertal (8–13 years), and adolescence (14–18 years). The retrospective study included patients with cSLE diagnosed at the Beijing Children’s Hospital between 2013 and 2021. Results A total of 675 females and 178 males were eligible for inclusion in this study. Among them, 160 patients were diagnosed during pre-puberty, 635 during peri-puberty, and 58 during adolescence. The female-to-male ratio of pre-pubertal, peri-pubertal, and adolescent diagnosis was 3.5: 1, 3.6: 1, and 7.28:1, respectively. The median time from onset to diagnosis during the pre-puberal period was 3.0 (IQR 1.0–24.0 months), which was longer than that during the peri-puberal period (1.4; IQR 0.7–4) months and adolescence (1.0; IQR 0.4–2) months ( p = <.0001). The proportion of LN in patients diagnosed during the peri-puberal period (304, 46.6%) and during adolescence (27, 47.9%) was higher than that of patients diagnosed during the pre-puberal period (59, 36.9%) ( p = .044). 46 (28.8%), 233 (36.7%), and 32 (55.2%) of children diagnosed during the pre-pubertal period, peri-pubertal period, and adolescence, respectively, suffered from leukopenia. Conclusion The proportion of renal involvement and leukopenia in the pre-pubertal group was lower than that o...