Photoinduced Copper-Catalyzed 1,2-Difunctionalization of 1,3-Dienes with Aryl Diselenides

作者：Shengkun Guo, Xiaoyu Shen, Xiaoyun Chen, Huaguang Yu, Ying Han, Chao‐Guo Yan, Yaocheng Shi, Hong Hou, Shaoqun Zhu · 发表于：The Journal of Organic Chemistry · 年份：2023 · DOI：10.1021/acs.joc.3c01181 · 被引用次数：17 · 研究领域：Sulfur-Based Synthesis Techniques、Organoselenium and organotellurium chemistry、Catalytic C–H Functionalization Methods

Described herein is a photoinduced copper-catalyzed 1,2-difunctionalization of 1,3-dienes. The selenium atom radical was generated by the visible light irradiation of diselenides, triggering radical addition with 1,3-dienes to form allyl radical intermediate. Subsequent rapid Z / E isomerization allowed for thermodynamically favorable intermediate formation and enabled copper catalyzed stereoselective functionalization with various nucleophiles.