Prognostic value of systemic inflammation and for patients with colorectal cancer cachexia

作者：Guo‐Tian Ruan, Hailun Xie, Kaitao Yuan, Shiqi Lin, Heyang Zhang, Chenan Liu, Jinyu Shi, Yi‐Zhong Ge, Mengmeng Song, Chunlei Hu, Xiaowei Zhang, Xiaoyue Liu, Ming Yang, Kunhua Wang, Xin Zheng, Yue Chen, Wen Hu, Minghua Cong, Li‐Chen Zhu, Li Deng, Hanping Shi · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2023 · DOI：10.1002/jcsm.13358 · 被引用次数：46 · 研究领域：Nutrition and Health in Aging、Inflammatory Biomarkers in Disease Prognosis、Muscle Physiology and Disorders

BACKGROUND: The development and progression of cancer cachexia are connected to systemic inflammation and physical performance. However, few relevant studies have reported the survival outcomes prediction of systemic inflammation and physical performance in patients with colorectal cancer (CRC) cachexia. This study investigated the prognostic prediction value of systemic inflammation and performance status in patients with CRC cachexia. METHODS: This multicentre cohort study prospectively collected 905 patients with CRC (58.3% males, 59.3 ± 11.5 years old). Cancer cachexia was diagnosed according to the 2011 Fearon Cachexia Diagnostic Consensus. The prognostic value of systematic inflammatory indicators was determined using the area under the curve, concordance index, and multivariate survival analysis. Performance status was evaluated with Eastern Coopertive Oncology Group performance score (ECOG-PS). Survival data were analysed using univariate and multivariate Cox regression analyses. RESULTS: The area under the curve, concordance index and survival analysis showed that C-reactive protein (CRP), lymphocyte to CRP ratio (LCR) and CRP to albumin ratio (CAR) were more stable and consistent with the survival of patients with CRC, both in non-cachexia and cachexia populations. Among patients with CRC cachexia, high inflammation [low LCR, hazard ratio (HR) 95% confidence interval (95% CI) = 3.33 (2.08-5.32); high CAR, HR (95% CI) = 2.92 (1.88-4.55); high CRP, HR (95% CI) = 3.12 ...