Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions

作者：Ryan Kammeyer, Ekemini A. Ogbu, Jennifer C. Cooper, Erin Stolz, Amanda L. Piquet, Robert C. Fuhlbrigge, Jeffrey L. Bennett, Christa Hutaff‐Lee · 发表于：Child Neuropsychology · 年份：2023 · DOI：10.1080/09297049.2023.2273573 · 被引用次数：10 · 研究领域：Systemic Lupus Erythematosus Research、T-cell and B-cell Immunology、Atherosclerosis and Cardiovascular Diseases

Cognitive dysfunction (CD) is a neurologic complication of pediatric systemic lupus erythematosus (SLE) that remains poorly understood and understudied, despite the potential negative effects of CD on long-term socioeconomic status and quality of life. Data regarding the prevalence and risk factors for CD in pediatric SLE as well as the optimal screening, treatment, and long-term outcomes for CD are lacking. In this review, we present current knowledge on CD in pediatric SLE with a focus on the application to clinical practice. We discuss the challenges in diagnosis, clinical screening methods, potential impacts, and interventions for this complication. Finally, we discuss the remaining gaps in our knowledge of CD in pediatric SLE, and avenues for future research efforts.