Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents

作者：Michelle Z. L. Kee, Andrea Cremaschi, Maria De Iorio, Helen Chen, Tina C. Montreuil, Tuong Vi Nguyen, Sylvana M. Côté, Kieran J. O’Donnell, Gerald F. Giesbrecht, Nicole L. Letourneau, Shiao‐Yng Chan, Michael Joseph Meaney · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.39942 · 被引用次数：36 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Gestational Diabetes Research and Management、Health, Environment, Cognitive Aging

Importance: Depressive symptoms during pregnancy influence the development and health of the offspring, underscoring the need for timely intervention. However, the course of depressive symptoms across the perinatal period remains unclear, thus complicating screening and referral guidelines. Objective: To examine the course and stability of depressive symptoms across the perinatal period in multiple, ethnically diverse independent observational cohorts. Design, Setting, and Participants: This cohort study included self-reported depressive symptoms at multiple time points from 7 prospective cohorts spanning 3 continents (United Kingdom: Avon Longitudinal Study of Parents and Children from 1991 to 1995; Canada: Maternal Adversity, Vulnerability and Neurodevelopment from 2003 to 2007; Montreal Antenatal Well-being Study from 2019 to 2022; Alberta Pregnancy Outcomes and Nutrition from 2009 to 2014; and Singapore: Growing Up in Singapore Toward Healthy Outcomes from 2009 to 2013; Singapore Preconception Study of Long-Term Maternal and Child Outcomes from 2015 to 2019; and Mapping Antenatal Maternal Stress from 2019 to 2022). Participants were recruited either during preconception or pregnancy and observed into the postnatal period. All data from each cohort were analyzed from July 2022 to April 2023. Main Outcomes and Measures: Self-reported depressive symptoms from pregnancy to 2 years following childbirth using either the Edinburgh Postnatal Depression Scale or the Center for Epi...