Two new alkaloids from the endophytic fungus Aspergillus fumigatus SAS10 isolated from the mangrove tree Sonneratia apetala

作者：Zanhong Chen, Haisheng Liu, Bo Ding, Siyu Guo, Hongbo Huang, Yiwen Tao · 发表于：Natural Product Research · 年份：2023 · DOI：10.1080/14786419.2023.2272289 · 被引用次数：10 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Marine Sponges and Natural Products

Two new alkaloids designated aspernigrin E (1) and pyranonigrin L (2) were isolated from mangrove endophytic fungus Aspergillus fumigatus SAS10, together with the known alkaloid compounds pyranonigrin A (3), asperazine (4), (+)-iso-pestalazine A (5), pestalazine A (6), and pestalazine B (7). The planar structures of the new compounds were elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configurations of compounds 1 and 2 were determined by comparison of the electronic circular dichroic (ECD) spectra with the calculated ECD spectra. All these compounds were tested for anti-bacterial activity.