Prognostic MRI features to predict postresection survivals for very early to intermediate stage hepatocellular carcinoma

作者：Hanyu Jiang, Yun Qin, Hong Wei, Tianying Zheng, Ting Yang, Yuanan Wu, Chengyu Ding, Victoria Chernyak, Maxime Ronot, Kathryn J. Fowler, Weixia Chen, Mustafa R. Bashir, Bin Song · 发表于：European Radiology · 年份：2023 · DOI：10.1007/s00330-023-10279-x · 被引用次数：26 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、MRI in cancer diagnosis、Organ Transplantation Techniques and Outcomes

OBJECTIVES: Contrast-enhanced MRI can provide individualized prognostic information for hepatocellular carcinoma (HCC). We aimed to investigate the value of MRI features to predict early (≤ 2 years)/late (> 2 years) recurrence-free survival (E-RFS and L-RFS, respectively) and overall survival (OS). MATERIALS AND METHODS: Consecutive adult patients at a tertiary academic center who received curative-intent liver resection for very early to intermediate stage HCC and underwent preoperative contrast-enhanced MRI were retrospectively enrolled from March 2011 to April 2021. Three masked radiologists independently assessed 54 MRI features. Uni- and multivariable Cox regression analyses were conducted to investigate the associations of imaging features with E-RFS, L-RFS, and OS. RESULTS: This study included 600 patients (median age, 53 years; 526 men). During a median follow-up of 55.3 months, 51% of patients experienced recurrence (early recurrence: 66%; late recurrence: 34%), and 17% died. Tumor size, multiple tumors, rim arterial phase hyperenhancement, iron sparing in solid mass, tumor growth pattern, and gastroesophageal varices were associated with E-RFS and OS (largest p = .02). Nonperipheral washout (p = .006), markedly low apparent diffusion coefficient value (p = .02), intratumoral arteries (p = .01), and width of the main portal vein (p = .03) were associated with E-RFS but not with L-RFS or OS, while the VICT2 trait was specifically associated with OS (p = .02). Multiple...