The Time‑Point Distribution Characteristics of Laryngopharyngeal Reflux in Elderly Patients

作者：Zhi Liu, Chun Zhang, Lianlian Liu, Jinhong Zhang, Xiaoyu Wang, Jiasen Wang, Jing Zhao, Shizhen Zou, Xin Ma, Jinrang Li · 发表于：Otolaryngology · 年份：2023 · DOI：10.1002/ohn.565 · 被引用次数：3 · 研究领域：Gastroesophageal reflux and treatments、Respiratory and Cough-Related Research、Dysphagia Assessment and Management

Abstract Objective To identify the characteristics of the time‐point distribution of the occurrence of hypopharyngeal‐proximal reflux episodes (HREs) in elderly and younger patients with laryngopharyngeal reflux (LPR). Study Design Retrospective cohort study. Setting Analysis of data from patients with LPR‐related symptoms and 24‑hour hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH (24‐hour HEMII‑pH) monitoring from February 2017 to September 2022 at Sixth Medical Center of PLA General Hospital. Methods Patients were divided into 2 age groups: the elderly group (>60 years) and the younger group (≤60 years). The time series of HREs and meals within 24 hours were analyzed based on HEMII‑pH. Results A total of 305 patients were included (126 elderly patients). In younger patients, except for nonacid‐gas HREs, the incidence of the remaining types of HREs tended to increase within 2 hours after meals, especially after dinner. The incidence of all types of HREs pre‐ and postmeal was not significantly different in the elderly group ( χ 2 = 0.080, P = .777). The incidence of nighttime HREs in elderly patients was statistically higher than in younger patients (6.23% vs 3.96%, P = .030), particularly acid‐/nonacid‐liquid HREs. Conclusion HREs tend to increase within 2 hours after meals in younger LPR patients, except for nonacid‐gas HREs. In elderly LPR patients, the incidence of all types of HREs pre‐ and postmeal were not significantly different, and nighttime flu...