Sanwei sandalwood decoction improves function of the gut microbiota in heart failure

作者：Kuiying Ma, Tingting Bai, Pengfei Hu, Ming Zhao, Zhi Xiu, SuRilige SuRilige, Dalintai Dalintai, Qingshan Zhang, Quan Wan · 发表于：Frontiers in Microbiology · 年份：2023 · DOI：10.3389/fmicb.2023.1236749 · 被引用次数：11 · 研究领域：Traditional Chinese Medicine Analysis、Plant-based Medicinal Research、Phytochemistry and biological activity of medicinal plants

Objective To investigate the effects of Sanwei sandalwood decoction on improving function of the intestinal flora in doxorubicin-induced heart failure in rats. Materials and methods Thirty Sprague–Dawley rats were screened and randomly assigned into a blank group, a model group, and a Sanwei sandalwood decoction group (treatment group). The rat model of heart failure was prepared and established in the latter two groups. After successful model establishment, the treatment group received Sanwei sandalwood decoction by continuous gavage at 2 g/kg, once daily for 4 weeks. The other groups were given an equivalent volume of saline. After the final dose, fecal samples were collected from each group and analyzed by macrogenomics and nontargeted metabolomics to characterize the intestinal flora and associated metabolites. Results The composition of gut microbiota was significantly different between the three groups. There were 778,808 common genes between the blank and model groups, while 49,315 genes were lost and 521,008 were gained in the model group relative to the blank group. At the phylum level, all groups of rat fecal samples were dominated by Firmicutes , Bacteroidota , Actinobacteria , and Proteobacteria . At the genus level, the microbial community composition in all experimental groups of rat fecal samples was dominated by Lactobacillus , Bifidobacterium , Limosilactobacillus , Allobaculum , Prevotella , and Ligilactobacillus spp. Interestingly, cluster analysis was perf...