Biventricular Dysfunction and Ventricular Interdependence in Patients With Pulmonary Hypertension: A 3.0‐T Cardiac MRI Feature Tracking Study

作者：Han F, Jin Wang, Rui Shi, Yuan Li, Xue‐Ming Li, Yue Gao, Liting Shen, Wen‐Lei Qian, Jiang Li, Zhi‐gang Yang · 发表于：Journal of Magnetic Resonance Imaging · 年份：2023 · DOI：10.1002/jmri.29044 · 被引用次数：12 · 研究领域：Pulmonary Hypertension Research and Treatments、Cardiovascular Function and Risk Factors、Cardiac Imaging and Diagnostics

BACKGROUND: Pulmonary hypertension (PH) results in right ventricular (RV) dysfunction, subsequently leading to left ventricular (LV) impairment. The mechanism underlying ventricular interdependence is largely uninvestigated. PURPOSE: To explore the biventricular dysfunction and the ventricular interdependence in PH patients. STUDY TYPE: Retrospective. POPULATION: One hundred and seven PH patients (mean pulmonary artery pressure >20 mmHg) and 72 age- and sex-matched controls with cardiac magnetic resonance imaging (MRI) studies. FIELD STRENGTH/SEQUENCE: 3.0 T/balanced steady-state free precession sequence. ASSESSMENT: LV and RV ejection fractions (EF) and RV and LV radial, circumferential, and longitudinal strains were assessed using commercial software. Strains were compared between controls, PH patients with preserved RVEF (RVEF ≥40%, N = 48), and PH patients with reduced RVEF (RVEF <40%, N = 59). STATISTICAL TESTS: Chi-squared tests or Fisher's exact test, t tests or Mann-Whitney U test, one-way ANOVA with Bonferroni's post hoc correction or Kruskal-Wallis test, Pearson or Spearman correlation, and multivariable linear regression analysis. A two-tailed P < 0.05 was deemed statistically significant. RESULTS: RV strain decreased sequentially from controls, through PH with preserved RVEF, to PH with reduced RVEF. PH patients with reduced RVEF had significantly lower LV strain, especially septal strain, and LV peak diastolic strain rate compared with both controls and PH patien...