S1032 Impact of Obesity and Metabolic Syndrome on Extraintestinal Manifestations of IBD

作者：Katie Hsia, Jennifer Youn, Surya Khadilkar, Tanya Zeina, Puja Rai, Akash Rastogi, Sureya Hussani, Samara Spence, Pranay Adavelly, J.M. de Miguel Yanes, Jacob Kotlier, Sonia Friedman, Alexander N. Levy · 发表于：The American Journal of Gastroenterology · 年份：2023 · DOI：10.14309/01.ajg.0000953768.51593.2b · 被引用次数：1 · 研究领域：Microscopic Colitis、Genetic factors in colorectal cancer、Inflammatory Bowel Disease

Introduction: The extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) have been seen at higher rates in patients with obesity. Adipose tissue has been demonstrated to promote proinflammatory states. Metabolic syndrome, a clinical condition of central obesity, dyslipidemia, hypertension, and impaired glucose metabolism, share features of immune dysregulation seen in IBD. We suspect that the systemic proinflammatory state of metabolic syndrome would lead to more EIM in patients with metabolic syndrome. Methods: Clinical data was extracted for patients with IBD seen from 1996-2022 at a tertiary medical center. Data collected includes BMI, metabolic syndrome, diabetes, hypertension, hyperlipidemia, and EIM. Obesity was defined as BMI >= 30 kg/m2. Relative risk with confidence intervals of 95% and Pearson’s Chi Squared with alpha 0.05 were calculated using Excel and EpiR. Results: There were 1418 patients with an average age of 45.6 years +/- 18.2 years and 49% were male. There were 724 (51%) patients with Crohn’s disease (CD) and 675 (48%) patients with ulcerative colitis (UC). EIM were found in 320 patients (23% of the sample). EIM were more common in patients with CD than UC (57% v 41%, P=0.01). The most common EIM was peripheral joint disease, which involved 180 patients (56% of patients with EIM). EIM were more common in IBD patients with obesity than in IBD patients who were not obese. Obese patients had higher rates of primary sclerosing cholangitis (PS...