Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

作者：Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas, Kaja Abbas, Mustafa Abbas, Sadia Abbasi, H Abbass, Anne L. Abbott, Nadine Abdallah, Ashraf Omar Abdelaziz, M Abdelfattah, Bushra Abdelqader, A Abdul, Basir Abdul, Sami Aftab Abdul, Abdul Rasheed, A Abdulakeem, Rezan A. Kadir, A Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, A Abeer Ul Amna, Laurent Abel, Kathy Abernethy, Movin Abeywickrema, C Abhinaya, Ahmad Farid Abidin, Adebanke Aboaba, A Aboagye-Odei, Christopher Aboah, Heba Aboelela, H Abo-Leyah, K Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, A Abousamra, M Abouzaid, Mathew Abraham, Tizzy Abraham, A. Abraheem, J Abrams, Richard Abrams, HJ Abu, Ahmad Abu-Arafeh, SM Abubacker, Akata Abung, Yousef Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Paul Acheampong, Sarah Acheampong, James Acheson, S Achieng, Andrés Acosta, R Acquah, Connor Acton, Jacqueline Adabie-Ankrah, Pauline Adair, AS Adam, Fiona Adam, Matthew Adam, Huzaifa Adamali, M Adamczyk, Christopher Adams, David H. Adams, Katie Adams, Lisa C. Adams, Nicholas M. Adams, Richard Adams, Tempestt Adams, L Adamu-Ikeme, Krishma Adatia, Kim G. Adcock, L Addai-Boampong, A. Addo, Oluwafemi Adeagbo, A Adebiyi, O. S. Adedeji, Yewande Adegeye, K Adegoke, Vicki Adell, Sherna Adenwalla, FW Adeoye, OA Adesemoye, EO Adewunmi, A Adeyanju, Joyce Adeyemi, Titilope A. Adeyemo, Bidur Adhikari, SA Adhikari, R Adhikary, A Aditya, P Adjepong, Gabrielle Adkins, Ahmad Adnan, M Adriaanse, J Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, P Afrim, FA Afriyie, ZA Aftab, Agnes Awuah, Mudit Agarwal, PN Agasiya, Rachel Agbeko, C Agbo, Sunil Aggarwal, A Aghababaie, L A Aguilar Jimenez, JA Agyekum, K Agyen, EK Ahadome, S Ahamed Sadiq, MH Ahammed Nazeer, M Ahmad, Saad Ahmad, A Ahmed, BAR Ahmed, Bilal Ahmed, Farhan Ahmed, Helal Uddin Ahmed, Irshad Ahmed, Kawsar Ahmed, L Ahmed, Muhammad S. Ahmed, MC Ahmed, MS Ahmed, Nausheen Ahmed, Nausheen Ahmed, Osama Ahmed, RA Ahmed, Rizwan Ahmed, Rizwan Ahmed, Sanam Ahmed, SG Ahmed, SH Ahmed, Rabeka Ali, Bilal A Mohamud, Sanam Ahmed, Sana Ahmer, A Ahonia, C Aidoo, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, L Aitken, B Ajay, Abdulakeem Ajibode, Ahdi Noomen Ajmi, Nahid Akhtar, Suha Akili, B Akinbiyi, O Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Muhammad Akram, Olugbenro Aktinade, U Akudi, ASAR Al Aaraj, Ali Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, A Alabi, Narendra Aladangady, Mahmoud Alafifi, AHM Khurshid Alam, Md. Samrat Alam, A Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, A. Albertus, Lorraine Albon, A Alcala, Gemma Alcorn, Stephen Alcorn, Andrés Gómez-Aldana, David Alderdice, A Aldesouki, Rayan Aldouri, Jonathan Aldridge, N. Aldridge, RM Ale, Ana Alegria, Amit Alexander, Craig J. Alexander, John H. Alexander, PDG Alexander, Julyan Al-Fori, Laith Alghazawi, O Alhabsha, Bahij Al-Hakim, R Alhameed, M Al-Hayali, Shams Al‐Hity, Ala Ali, FR Ali, Johar Ali, Mohammad Ali, MS Ali, Nayab Ali, Omar Hasan Ali, R Ali, Syed Ahsan Ali, E Aliberti, J Alin, Abid Alina, A Alipustain, Bachti Alisjahbana, Fine Aliyuda, Kaveh Alizadeh, Maithem Al-Jibury, S Al-Juboori, M Al-Khalil, A Alkhudhayri, Moutaz Alkhusheh, Frank N. Allan, Nicholas P. Allan, Alison Allanson, Robert Allcock, Emma Allen, Jason W. Allen, Keeley Allen, Louise Allen, Pamela B. Allen, R Allen, Stephen Allen, Tammy D. Allen, A Alli, Kelly C. Allison, Brent E. Allman, HK Allsop, Lynne Allsop, David Allsup, AFT Almahroos, Hassan Al-Moasseb, M Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Z Al-Saadi, R Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, F Alsheikh, B Al-Sheklly, Sana Altaf, A Alty, Míriam J. Álvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, N Amar, S Ambalavanan, Robert Ambrogetti, Christopher S. Ambrose, A Ameen, A Amelia Ganefianty, Katharine Ames, M. R. Amezaga, A Amin, A Amin, Kawa Amin, S Amin, Tarek Tawfik Amin, B Amit, Awais Amjad, Nasser Mohammad Amjad, J Amoah-Dankwa, Amos Amoako-Adusei, Victoria Amosun, M Amsal, Khaled Amsha, John Amuasi, Noelia Martín, Pugh Amy, A Anada, Atul Anand, Samantha Anandappa, SD Anantapatnaikuni, NKN Andari, Élizabeth Anderson, Jennifer Anderson, Laura Anderson, Michelle A. Anderson, Neil W. Anderson, Rory Anderson, Susan M. Anderson, Wendy G. Anderson, Penny Andreou, A Andrews, James S. Andrews, Kanayochukwu Aneke, Andrew Ang, WW Ang, Tiffany A. Angel, Angela Angela, Paola Angelini, L Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, L Anning, Michael Owusu-Ansah, PJ Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Vaibhav Anu, Muhammad Naveed Anwar, Sibtain Anwar, E Apetri, A Apostolopoulos, S Appleby, Diane Appleyard, MF Aquino, Bianca Araba, Samuel Aransiola, Matheus Lucas De Araújo, Amena Archer, D.F. Archer, Simon Archer, D Arcoria, Christian Ardley, G Arhin-Sam, A-M Arias, O Aribike, R. Arimoto, NLPE Arisanti, C Arkley, Charlotte Armah, Ilianna Armata, Jennifer Armistead, Andrew E. Armitage, Courtney Armstrong, Maggie Armstrong, Sarah Armstrong, Wendy S. Armstrong, Philippa Armtrong, H Arndt, Clare Arnison-Newgass, David Arnold, Roland Arnold, Alicia Arnott, D Arora, Kanika Arora, Prateek Arora, Rakesh C. Arora, Arslam Arter, Adam S Arthur, NM Artini, A Arumaithurai, A Arya, Rita Arya, Diptesh Aryal, Denisa Asandei, GA Asare, Asma Asghar, Muhammad Asghar, Arif Ashab, Catherine Ashbrook-Raby, Helen Ashby, James Ashcroft, S. J. H. Ashcroft, Gary Asher, Z Ashfak, Akhtar Ashfaq, HA Asiamah, Abdul Ashish, Dennis W. Ashley, Sally Ashman-Flavell, S Ashok, A-E-A Ashour, MZ Ashraf, Saima Ashraf, MB Ashraq, Deborah Ashton, S. Ashton, Andrew Ashworth, F. Ashworth, R Ashworth, Ayesha Aslam, I Aslam, Sadaf Aslam, Laura Aslett, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, YE Atabudzi, P Athavale, Deborah Athorne, Billie Atkins, C D Atkins, Salla Atkins, John Atkinson, V Atkinson, Abolaji Atomode, Brygitta Atraskiewicz, AA Attia, E Attubato, Marie Attwood, Paula Aubrey, Z Auer, Avinash Aujayeb, AT Aung, Hnin Aung, HWW Aung, KK Aung, KT Aung, Nay Aung, Ye Myint Aung, ZM Aung, Emily Austin, Karen Austin, A Auwal, M Avari, Mary Ellen Avery, Nicholas Aveyard, Joanne Avis, Georgina Aviss, Cristina Avram, Paula Avram, A Awadelkareem, Gabriel Awadzi, Mahmoud Awaly, Ali Raza Awan, S Awisi, A Aya, Elif Yıldırım Ayaz, JM Ayerh, Alessandra T. Ayers, J Azam, Asmaa Azeem, M Azharuddin, Ayesha Aziz, G Aziz, Imran Aziz, N Aziz, Ali Azkoul, Abdullah Shah, Gabriella Azzopardi, Hocine Azzoug, Oluwasola Babatunde, Monika Novak Babič, B Babiker, G Babington, Matthew Babirecki, Marta Babores, AO Babs-Osibodu, T Bac, Sammy Bacciarelli, Rachel Bachar, M-E Bachour, A Bachti, G. E. Bacon, Joanna Bacon, Bibi Badal, A Badat, Michael Bäder, GR Badhan, Shreya Badhrinarayanan, JP Bae, Alice Baggaley, Amy Baggott, GRANT P. BAGLEY, Dinesh Bagmane, Lynsey Bagshaw, K Bahadori, Yogesh Bahurupi, Adam L. Bailey, James Bailey, Katherine Bailey, L. Charles Bailey, Marc A. Bailey, Melanie J. Bailey, Paul Bailey, Stephen J. Bailey, Hamish Baillie, J. Kenneth Baillie, Jennifer Bain, Vikram Bains, Denis Baird, Emily Baird, Kathleen Baird, Susan Baird, T Baird, Yolanda Baird, Aiysha Bajandouh, DC Baker, Elizabeth Baker, J Baker, Kylie Baker, Michelle L. Baker, Rebecca Baker, T-A Baker, Victoria Baker, Hugh Bakere, Nawar Diar Bakerly, Michelle Baker-Moffatt, Ameet Bakhai, Nauman Bakhtiar, Panos Bakoulas, D Bakthavatsalam, N Balachandran, A. Balan, P Balasingam, Theodosios Balaskas, Madhura Balasubramaniam, N Balatoni, Alison Balcombe, Alexander J. Baldwin, Alexander J. Baldwin, Carol M. Baldwin, David Baldwin, F Baldwin, Rebekah Baldwin-Jones, Nichola Bale, James Balfour, Matthew Ball, Ro Ball, K Ballard, Ismael Balluz, Craig Balmforth, Emese Balogh, A Baltmr, Amir Baluwala, Gabby Bambridge, Amy Bamford, Peter Bamford, Adefunke Bamgboye, Elizabeth Bancroft, Hollie Bancroft, Jethro Banda, Krishna Bandaru, Srini Bandi, Nageswar Bandla, Somaditya Bandyopadhyam, Amitava Banerjee, Rajarshi Banerjee, Peter Bang, S Baniya, O Bani-Saad, Helen Banks, Lauren B. Banks, Paul Banks, Carla Bann, H Bannister, Oliver Bannister, Laura Banton, Ting Bao, M Baptist, Tanya Baqai, AM Baral, Sagun Baral, Desislava Baramova, Russell Barber, E Barbon, Márcia M. Barbosa, Jamie Barbour, Andrew R. Barclay, Colleen Barclay, George Bardsley, Stephanie Bareford, Md Shafiqul Bari, Morris Barimbing, Anna D. Barker, Debbie Barker, Erin Barker, Helen Barker, Joseph Barker, Lindsay Barker, Oliver Barker, Kerry Barker-Williams, Sinha Barkha, J Barla, Gavin Barlow, Richard Barlow, Valerie Barlow, James Barnacle, Amanda Barnard, David Barnes, Nicola Barnes, R Barnes, Thomas W. Barnes, Calum Barnetson, Adrian Barnett, Ashton Barnett‐Vanes, PG Barning, William Barnsley, Andrew Barr, David Barr, James W. Barr, Charles E. Barr, N Barratt, Shaney Barratt, Manuel Barrera, Amy Barrett, Fi Barrett, Jessica Barrett, Sarah Barrett, E Barrow, John R. Bartholomew, M.S. Barthwal, Chris Bartlett, Gillian Bartlett, J. M. S. Bartlett, Lucas E. Bartlett, S. Howard Bartley, S Bartolmeu-Pires, Alan W. Barton, Greg Barton, Janet Barton, Lisa M. Barton, Rachael Barton, Resham Baruah, S Baryschpolec, Humayun Bashir, Archana Bashyal, Betsy Basker, S Basnet, Buddha Basnyat, Ahmet Başoğlu, A Basran, John Bassett, G Bassett, Christopher Bassford, Bengisu Bassoy, Victoria Bastion, Anup Bastola, Anupam Basumatary, Precious Basvi, JA Batac, VR Bataduwaarachchi, T Bate, H. Bateman, Kathryn M. Bateman, Vhairi Bateman, Eric Bates, Hayley Bates, M. Bates, Simon Bates, Sally Batham, Ana Batista, Amit Batla, Dushyant Batra, Harry Batty, Thomas Batty, A Batty, Micha Baum, Rachel Baumber, Carles Bautista-Rodríguez, Flavia Kaduni Bawa, T Bawa, FS Bawani, Simon Bax, Mark Baxter, Nancy N. Baxter, Zachary Baxter, Hannah Bayes, L-A Bayo, Farid Bazari, Rohit Bazaz, Ahmad Bazli, Laura Beacham, Wendy Beadles, Kirsten Beadon, Philip Beak, Andy Beale, Kate Beard, Jack Bearpark, Anne Beasley, Scott Beattie, Katy Beaumont, Dawn Beaumont-Jewell, Thomas M. Beaver, Sarah Beavis, Christy Beazley, Sarah E. Beck, V Beckett, Rosie Beckitt, S. Beckley, Heidi Beddall, Simon Beddows, Deborah Beeby, Steve Beeby, Gail Beech, Mary Louise Beecroft, Nicola L. Beer, Sa Beer, J Beety, Gabriela Bega, Adrian C. Begg, Stephen Begg, Sara Beghini, Ayesha Begum, Selina Begum, Selina Begum, Teresa Behan, Roya Behrouzi, Jon Beishon, C Beith, James Belcher, Holly Belfield, Katherine Belfield, Ajay Belgaumkar, D Bell, Gregory Bell, Jennifer Bell, L. Bell, N.J. Bell, P Bell, Stephanie Bell, Jennifer Bellamu, Michael Bellamy, T Bellamy, Antonio Bellini, A Bellis, Fionn Bellis, Linda J. Bendall, Naveena Benesh, Nicola Benetti, SA Bengu, L Benham, Guy Benison-Horner, Sarah Benkenstein, T Benn, Aisleen Bennett, Caroline Bennett, David Bennett, Gary G. Bennett, Katherine Bennett, Katherine Bennett, Louise Bennett, MR Bennett, Stephen Bennett, Kelly A. Bennion, G Benoy, Vivienne Benson, Andrew Bentley, James Bentley, Ian Benton, Eva Beranová, Michael W. 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Bolger, Candice Bonaconsa, Christopher Bond, Hannah Bond, Simon Bond, T Bond, Anna E Bone, Georgia Boniface, Joseph Bonney, Loida Bonney, Lynda Booker, S Boot, M Boothroyd, Joanne Borbone, Naomi Borman, S Bosence, K Bostock, Nicola Botting, Fiona Bottrill, H Bouattia, Laura Bough, Hayley Boughton, Zoe Boult, T Boumrah, Michael J. Bourke, Stephen C Bourke, Michelle Bourne, Rachel Bousfield, Lucy Boustred, Ali Bowes, Paul Bowker, T Bowker, Helen Bowler, Louise Bowman, Simon Bowman, Rachel Bowmer, A Bowring, Helen Bowyer, A Boyd, J. Gordon Boyd, Lydia Boyd, Naomi Boyer, N Boyle, Peter Boyle, R Boyle, Louise Boyles, L Brace, A Bracken, Jodie Bradder, C. Bradley, Paul Bradley, Joanne Bradley-Potts, Luke Bradshaw, Zena Bradshaw, Charles E. Brady, R Brady, S Brady, P Braga Sardo, Denise Braganza, M. 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Titus Brown, Ellen Brown, Heather Brown, Jeremy Brown, Louise Brown, Nicholas M. Brown, Pauline Brown, Rosemary Brown, Samuel M. Brown, Thomas Brown, Bill Browne, Cameron J. Browne, Duncan L. Browne, Matthew Browne, Shannon Brownlee, Alba Brraka, Johanna Bruce, Michael G. Bruce, Wojciech Brudlo, A Brunchi, Nigel J. Brunskill, Amanda E. Brunton, Margaret Brunton, Maria Bryant, E Bryden, H Brzezicki, April Buazon, MH Buch, Rachel Buchan, R Buchanan, D Buche, Amanda Buck, Linda B. Buck, Matthew Buckland, C Buckley, Laura Buckley, Philip Buckley, Sarah Buckley, Cierra Buckman, A Budds, George Bugg, Ramadan Bujazia, Marwan Bukhari, Syed Bukhari, Richard Bulbulia, Anthony M. J. Bull, Dale Bull, Katherine R. Bull, Rowena A. Bull, Th Bull, E Bullock, S Bullock, Naomi Bulteel, Kasun Bumunarachchi, Roneleeh Bungue-Tuble, O Burbidge, Chelsie O. Burchett, D Burda, Christy Burden, TG Burden, Mi Burgess, Richard Burgess, Stephen Burgess, Erlina Burhan, Hassan Burhan, Hannah Burke, Katherine Burke, Alison Burman, Sara Burnard, Catherine Burnett, Scott Burnett, Angus C. Burns, C Burns, James E. Burns, Karen E. A. Burns, Daniel Burrage, Kate Burrows, Claire Burston, Adrian Burton, Bradley Burton, Fiona Burton, H. Burton, Maudrian Burton, Mannaria Butar butar, D Butcher, Andrew J. Butler, Elaine Butler, Jessica Butler, Peter Butler, Susan Butler, Jessica Butler, A-T Butt, Muhammad Hammad Butt, MM Butt, Chris Butterworth, Nicola Butterworth‐Cowin, Robert Buttery, T Buttle, Heather Button, Daniel Buttress, Hannah Bye, J Byrne, William J. Byrne, Victoria Byrne-Watts, Amanda Cabandugama, L Cabrero, Sarah Caddy, Robert Cade, Anthony Cadwgan, Z Cahilog, Ajeng Cahyareny, Donna Cairney, James Calderwood, Darren Caldow, E Calé, G Calisti, Debbie Callaghan, John J. Callaghan, Claire Callens, D Callum, Clive R. Calver, Melissa Cambell-Kelly, Tracey Camburn, DR Cameron, Emily A. Cameron, Fraser Cameron, Scott J. Cameron, C Fielder Camm, FD Cammack, Andrew Campbell, Bridget Campbell, Danielle Campbell, Helen Campbell, Jonathan D. Campbell, Kieran R. Campbell, Mark Campbell, Ryan Campbell, W Campbell, Quentin Campbell Hewson, Julie Camsooksai, Lisa Canclini, SM Candido, J Candlish, Cielito Caneja, A Cann, J Cann, Ruby Cannan, Andréa Cannon, E Cannon, Mary Cannon, Paul Cannon, V Cannons, E Canonizado, Jane Cantliff, Neşe Kanbal Çap, Ben Caplin, Santino Capocci, Noemi Caponi, Anne Capp, Richard Capstick, Toby Capstick, C Caraenache, A Card, Mary Cardwell, Charles Carey, Rachel Carey, Simon Carley, Ffion Carlin, Tammy Carlin, S Carmichael, M. Carmody, Mandy Carnahan, Charlotte Caroline, James R. Carpenter, Sue Carr, Araceli Ramos Carrasco, Zoe Carrington, Aaron E. Carroll, Paul Carroll, Richard T. Carson, C Cart, E Carter, Jonathan Carter, M Carter, N Carter, P Carter, Douglas Cartwright, J-A Cartwright, Cara L. Carty, Lucy Carty, Jaime Carungcong, Catherine Carver, E Carver, Richard Carver, Susan A. Casey, Andrea Cassells, Teresa Castiello, G. Castle, Bridget Castles, Melanie Caswell, AM Catana, Hugo Ten Cate, Anelise Catelan Zborowski, Susanne Cathcart, Katrina Cathie, D Catibog, Christine Catley, Laura Catlow, Matthew Caudwell, Anna Cavazza, Adele E. Cave, L Cave, Silvia Cavinato, Frianne Cawa, Kathryn Cawley, C Caws, K Cawthorne, Hankins Cendl, Hannah Century, Jeva Cernova, Mansur Cesay, Ed Cetti, Stephanie Chabane, Manish Chablani, Cathleen Chabo, J Chacko, David Chadwick, Jim Chadwick, Ruth Chadwick, Ela Chakkarapani, Arunangshu Chakraborty, Mallinath Chakraborty, Mollika Chakravorty, P Chalakova, BS Chalise, James D. Chalmers, Richard Chalmers, G Chamberlain, Sarah Chamberlain, Emma S. Chambers, Jonathan Chambers, Lucy Chambers, Naomi Chambers, Andrew Chan, Chak K. Chan, E Chan, Michael Chan, Karina Chan, PK Chan, Ricky Chan, XHS Chan, Chris Chandler, Xin Hui S Chan, KJ Chandler, S Chandler, Zoe Chandler, Subhash Chandra, N Chandran, Badrinathan Chandrasekaran, Yu-Jun Chang, HQ Chanh, G Chaplin, J Chaplin, G Chapman, John Chapman, K Chapman, Lloyd A. C. Chapman, Marianne J. Chapman, P Chapman, Tracy Chapman, Lucy C. Chappell, A Charalambou, B Charles, Dianne Charlton, Sue Charlton, Kevin Chatar, Calvin Chatha, D Chatterton, Nguyễn Văn Vĩnh Châu, Ritesh Chaube, MYN Chaudhary, Bulbul Chaudhary, Imran B. 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Chiu, L Chiverton, Brenda Chivima, Catherine Chmiel, Sungyeon Choi, Willy Choon Kon Yune, Manu Chopra, Vijayanand Choudhary, O Choudhury, Sarah Choudhury, B-L Chow, Madiha Chowdhury, Sharfuddin Chowdhury, A Chrisopoulou, Victoria Christenssen, Peter Christian, Alexander Christides, Fiona Christie, D Christmas, G Christoforou, T Christopherson, Andrea Christou, M. Christy, P Chrysostomou, Y Chua, Dip Chudgar, Richard Chudleigh, Srikanth Chukkambotla, ME Chukwu, Izu Chukwulobelu, CY Chung, Elaine Church, SR Church, David Churchill, Nicole Cianci, Paola Cicconi, Paola Cinardo, Zdenka Cipinova, B Cipriano, Susan Clamp, Bridget Clancy, Matthew Clapham, Edel Clare, Sarbjit Clare, Andrew Clark, Collin M. Clark, Diane Clark, Edward G. Clark, Felicity Clark, Gemma Clark, James Clark, Katy M. Clark, Louise L Clark, Michele Clark, Nathaniel G. Clark, Patricia C. Clark, Richard Clark, Thomas A. Clark, Zoë Clark, A.M. Clarke, Jennifer Clarke, Paul Clarke, Robert W. Clarke, Samantha Clarke, Alleyna Claxton, Lindsay Claxton, Kate Clay, C Clayton, Emily Clayton, Olivia Clayton, Jill Clayton‐Smith, B Clearyb, Chris Cleaver, R Cleeton, I Clement', Carlota Clemente de la Torre, J Clements, S. Clements, S Clenton, S Cliff, R Clifford, Sarah Clifford, Amelia Clive, John Clouston, V Clubb, Samantha Clueit, L Clutterbuck, Ailis Clyne, M. Coakley, PGL Coakley, Kathryn Cobain, A Cochrane, P. Cochrane, L Cockayne, Maeve Cockerell, Helen Cockerill, S Cocks, Rachel Codling, Antoinette B. Coe, S Coetzee, David Coey, David J. Cohen, Jonathan B. Cohen, Oliver C. Cohen, Marita Cohn, Louise Coke, Olutoyin Coker, Nicholas Colbeck, Robert Colbert, Edward Cole, Jade Cole, Grahame J. Coleman, Melissa H. Coleman, Nick Coleman, H Coles, M Colin, Alicia Colino-Acevedo, J Colley, Kate Collie, A. Collier, David Collier, Hilde Collier, T Collingwood, Paul Collini, Érin Collins, Joanne Collins, Katy Collins, Michael Collins, Nicola Collins, Sean P. 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Madu, Lorraine Madziva, Marion Mafham, N Magee, Frederick Magezi, Negar Maghsoodi, Christopher Magier, LM Magnaye, Marios Magriplis, M Magtalas, Nombulelo Magula, Natasha Mahabir, Subramanian Mahadevan-Bava, Sudhanshu Mahajan, Amitaa Maharajh, Kijan Maharjan, Manita Maharjan, Ajit Mahaveer, Bal Mahay, Kanta Mahay, Adam Mahdi, Hibo Mahdi, Noor Mahdi, Thabo Mahendiran, Siva Mahendran, Sarah Maher, A Maheswaran, S Maheswaran, T Maheswaran, Parisa Mahjoob-Afag, Ahmed Mahmood, Faisal Mahmood, Hana Mahmood, Waheed Mahmood, Zahed Mahmood, Hossam Mahmoud, Melati Mahmud, Ewan Mahony, Tabitha Mahungu, Oumou Maïga, Luke Mair, Toluwani Majekdunmi, Kamran Majid, Angela M. Major, Rupert Major, Jaydip Majumdar, MKH Majumder, TLA Mak, Abdelhadi Makan, Esther Makanju, Stephen Makin, W-O Makinde, Y Makkeyah, ON Makoetlane, Marius Malanca, Helen Malcolm, Flora Malein, Neeraj Malhan, Alicja N. Malicka, Abdul Malik, G Malik, Mohammed Maljk, Peter Mallett, Petrina Mallinder, Georgia Mallison, Louise Mallon, Edward Malone, Gerald E. Maloney, Mohammed Mamman, I Man, Kenneth K. C. Man, Rosa Mancinelli, Marco Mancuso-Marcello, SK Mandal, Sema Mandal, Tracy Manders, Lenore Manderson, Justin Mandeville, T Mane, R Manhas, Carmela Maniero, Ravi Manikonda, I Manjra, R Mankiewitz, B Mann, Jonathan Manning, Susan E. Manning, P Mannion, Kamal Mansi, K Manso, Dina Mansour, Michael K. Mansour, Rita Mansour, IT Mapfunde, Predeesh Mappa, Afsheen Maqsood, Hemant Maraj, Clare Marchand, Neil Marcus, A Marcyniuk, Maria Marecka, D Maren, G Margabanthu, Jordi Margalef, Lavinia Margarit, Georgios Margaritopoulos, Michael Margarson, F Maria del Rocio, Teresa Maria Pfyl, V. Mariano, Andreja Marić, G Markham, Brynn E. Marks, Michael Marks, P Marks, E Marler, E Marouzet, Anna Marriott, C Marriott, Neil Marriott, C Marsden, K Marsden, Peter V. Marsden, Sarah Marsden, Tracy Marsden, Chris Marsh, Glenn A. Marsh, Regan H. Marsh, Andrew Marshall, Andrew Marshall, Gary S. Marshall, Henry Marshall, John C. Marshall, John C. Marshall, N. Marshall, Randolph S. Marshall, Skye Marshall, John C. Marshall, E Martin, Greg S. Martin, Hilary C. Martin, Jane Martin, Katy Martin, Laila Abdel‐Kader Martín, María Martin, Noelia Martín, Thomas Martin, Winston Martin, Suzanne Martin, Tim Martindale, Marcus Martineau, Leonardo Martínez, JC Martinez Garrido, Juan Martín-Lázaro, VK Maruthamuthu, B Marwan, Gemma Maryan, Roman Mary-Genetu, Sam Maryosh, V Masani, A. Mascagni, Diego Maseda, Zandile Maseko, Sheila Mashate, Yasaman Mashhoudi, Al Mashta, Izhaq Masih, S. Masih, Nick Maskell, Perry Maskell, P Maskey, Matthew Masoli, J. H. Mason, Ronald P. Mason, Christopher E. Mason, Mehvish Masood, MT Masood, SSME Masood, T. Massa, Ian J. Massey, J Masters, Arif Masud, Lear Matapure, Cristina Matei, Ropafadzo Matewe, E Matey, Manjit Matharu, Stephy Mathen, Alison E. Mather, Nancy Mather, Jonathan Mathers, Jesse Matheson, Anna Mathew, Anna Mathew, M Mathew, V Mathew, John Mathews, Kate Mathias, Alexander G. Mathioudakis, S Matibela, Darwin Matila, Wadzanai Matimba-Mupaya, Nassim Matin, Elina Matisa, E Matkins, Max Matonhodze, Enock Matovu, Jaysankar Mattappillil, AJ Matthews, Claire Matthews, Helen Matthews, Lehentha Mattocks, Charlotte Maughan, TT Maulidya, E Mawson, Fiona Maxton, Adam D. Maxwell, Victoria Maxwell, Elisabeth S. May, James E. May, P. May, Irving Mayanagao, Matthew Maycock, Jean Mayer, G Mayers, VA Maynard, Kaitlin J. Mayne, T Mayo, L Mayola, S. Mayor, Ibreaheim Mazen, T Mazhani, Andrea Mazzella, Nyambura Mburu, A Mbuyisha, C Mc Cague, Eleanor McAleese, Paul McAlinden, Lucy McAllister, Alastair McAlpine, Graeme McAlpine, Joseph McAndrew, Hamish McAuley, Shane McAuliffe, Claire McBrearty, Emily McBride, Michael McBuigan, J McBurney, Laura R. McCabe, GL McCafferty, Laura McCafferty, Amanda McCairn, J. Andrew McCammon, Nicole McCammon, Conor J. McCann, Edward McCann, Alexandra McCarrick, Brendan McCarron, Eoghan McCarthy, Mark I. McCarthy, Natalie McCarthy, Sinead McCaughey, Tara McClay, Beverley McClelland, Declan McClintock, M McCloskey, Katie McCollum, A McCorkindale, Patricia McCormack, Jacqueline McCormick, W McCormick, P McCourt, Julie S. McCrae, S. McCready, Graham A. McCreath, Helen McCreedy, Carolyn M. McCue, I McCullagh, Laura McCullagh, Marjorie C. McCullagh, Colleen McCullough, Katherine McCullough, N. McCullough, S McCullough, Fiona McCurrach, Jaime McDermott, Philip McDermott, Ray McDermott, K McDevitt, Helen McDill, Bruce D. McDonald, Carrie R. McDonald, Deborah Dillon McDonald, Robert H. McDonald, Sarah McDonald, Deborah Dillon McDonald, Nolan McDonnell, Cameron G. McDougall, Laura McDougall, Rosalind McDougall, I McEleavy, Fred McElwaine, Julie McEntee, Evanna McEvoy, Cheryl McEwan, Ruth McEwen, M McFadden, Deborah A. McFarland, Mary McFarland, Rachel McFarland, J McFlynn, E McGarry, Lorcan McGarvey, A McGeachan, Frank McGee, Laura McGenily, Carolyn McGettigan, Michael McGettrick, C McGhee, Fiona McGill, Sarah McGinnity, Neil McGlinchey, Pauline McGlone, D McGlynn, C McGoldrick, Edwin C. McGough, Colleen McGovern, Ruth McGovern, Andrew J. McGowan, Andrew McGown, Brendan McGrath, A McGregor, MP McGuigan, Heather McGuinness, Sean P. McGuire, Timothy D. McHugh, Caroline McInnes, Natalia McInnes, J McIntosh, Karen McIntyre, Mark McIntyre, L. D. McKay, CP McKeag, J McKeane, Martin McKee, J McKeever, James McKenna, Sonia McKenna, Michael W. McKenzie, Donogh McKeogh, Caroline McKerr, AM McKie, Hayley McKie, Lisa McKie, Gerard McKnight, Helen McLachlan, A McLaren, B McLaren, Nicola McLarty, Danielle McLaughlan, M McLaughlin, James S. McLay, Mary McLeish, Tina McLennan, Stewart McLure, AM McMahon, Genevieve McMahon, Michael McMahon, Stephen McMahon, Terence McManus, Mitchell McMaster, Paddy McMaster, Paddy McMaster, F Mcmeeken, Scott McMeekin, Nigel A.J. McMillan, K McMillen, J McMinn, Liam McMorrow, Heather McMullen, Christopher E McMurran, Helen McNally, Fiona McNeela, Lynne McNeil, C. McNeill, J McNeill, Shalene H. McNeill, Una McNelis, Moira McNulty, Richard McNulty, Colm McParland, Mark McPhail, Alison McQueen, Anna McSkeane, Denise McSorland, T McSorley, Gini McTaggart, Jacqueline McTaggart, Judy Mead, Paul S. Mead, E Meadows, O Meakin, Ben Mearns, C Mearns, Kim Mears, William Mears, Manjula Meda, Ayren Mediana, Ross Medine, Thomas Medveczky, S Meehan, Emily Meeks, A Megan, Nevan Meghani, Salim Meghjee, S Megson, A Mehar, MN Mehmood, Renée Mehra, Ravindra L. Mehta, Graeme Meintjes, J Meirill, James Meiring, Ramzi Mejri, E Mekonnen, Sheila Melander, A-S Melinte, J Mellersh, L Melling, Chris Mellish, Francesca Mellor, Joseph Mellor, Sophie Mellor, Zoe Mellor, Katrina Mellows, Vladimir Melnic, Andrew Melville, David M. Melville, J Melville, Helen Membrey, Mark Mencias, Adam Mendelski, Marc Mendelson, C. Mendonca, C Meney, Colin Menezes, W Mensah, JE Mensshan, Alexander J. Mentzer, Dan Menzies, Sarah Menzies, Stephen Mepham, Oliver Mercer, P. Mercer, Almas Merchant, Fatima A. Merchant, Mihaela Mercioniu, Mark Meredith, Marta Merida Morillas, Blair Merrick, John Merritt, S Merritt, P Merron, Ekta Merwaha, Simon Message, John C. Messenger, Gabriel Metcalf-Cuenca, Amy Metcalfe, Benjamin Metcalfe, Kelly Metcalfe, Stella Metherell, Aleksandra Metryka, Louise Mew, Simon Meyrick, Nhlanhla Mguni, J Mhlongo, Atiqa Miah, Jagrul Miah, N Miah, Areeb Mian, Gabriela Mic, L Micah-Amuah, Dariush Micallef, A Michael, S Michael, Natalia Michalak, Loredana Michalca-Mason, O Michalec, Jonathan Middle, H Middleton, Joanna Middleton, Maeve Middleton, S Middleton, Shelley Mieres, Loredana Mihalca-Mason, Theresia Mikolasch, Sarah Milgate, Colin Millar, Johnny Millar, Jeremy Millard, David Miller, Jennifer R. Miller, Lucy Miller, Rachel K. Miller, Naomi Miller-Biot, Alex Miller-Fik, Louise Millett, Barry Milligan, Hazel Milligan, Iain Milligan, Charles S. Milliken, Katherine Millington, Rob Millington, Scott J. Millington, Helen Mills, Janet Mills, Rebecca Mills, Hugh Millward, Rebecca Miln, Alice Milne, Christopher J. Milne, Lynsey Milne, Joshua D. Milner, L Milner, Z Min, Samuel Mindel, Nguyen Q. Minh, PA Minkah, Chrissie Minnis, Paul Minnis, K Minou, Natalie Minskip, Jane Minton, Fabrizio Miranda, M Mirela, Taimur Mirza, Anjum Misbahuddin, Aseem Mishra, Brijesh Kumar Mishra, Eleanor Mishra, Rajesh Mishra, S Misra, Dina Mistry, H Mistry, Dushyant Mital, Sarah Mitchard, Brett Mitchell, Christopher Mitchell, LJ Mitchell, Piers D. Mitchell, Philip Mitchelmore, Andrew Mitra, Andrew Mitra, Sandip Mitra, N Mlambo, Emma Moakes · 发表于：The Lancet Diabetes & Endocrinology · 年份：2023 · DOI：10.1016/s2213-8587(23)00253-x · 被引用次数：41 · 研究领域：Diabetes Treatment and Management、Hyperglycemia and glycemic control in critically ill and hospitalized patients、COVID-19 Clinical Research Studies

BACKGROUND: Empagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess its safety and efficacy in patients admitted to hospital with COVID-19. METHODS: In the randomised, controlled, open-label RECOVERY trial, several possible treatments are compared with usual care in patients hospitalised with COVID-19. In this analysis, we assess eligible and consenting adults who were randomly allocated in a 1:1 ratio to either usual standard of care alone or usual standard of care plus oral empagliflozin 10 mg once daily for 28 days or until discharge (whichever came first) using web-based simple (unstratified) randomisation with allocation concealment. The primary outcome was 28-day mortality; secondary outcomes were duration of hospitalisation and (among participants not on invasive mechanical ventilation at baseline) the composite of invasive mechanical ventilation or death. On March 3, 2023 the independent data monitoring committee recommended that the investigators review the data and recruitment was consequently stopped on March 7, 2023. The ongoing RECOVERY trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). FINDINGS: Between July 28, 2021 and March 6, 2023, 4271 patients were randomly allocated to receive either empagliflozin (2113 patients) or usual care alone (2158 patients). Primary and secondary outcome data were known for greater than 9...