Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

作者：Nan Wang, Yongliang Yao, Yingfen Qian, Dewen Qiu, Hui Cao, Huayuan Xiang, Jianjun Wang · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1254347 · 被引用次数：14 · 研究领域：Extracellular vesicles in disease、MXene and MAX Phase Materials、MicroRNA in disease regulation

Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nucleic acids or lipids released from host cells are altered following infection with Mycobacterium tuberculosis . Exosomal contents provide excellent biomarkers for the auxiliary diagnosis, efficacy evaluation, and prognosis of tuberculosis. This study aimed to review the current literatures detailing the functions of exosomes in the procedure of M. tuberculosis infection, and determine the potential values of exosomes as biomarkers to assist in the diagnosis and monitoring of tuberculosis.