Evidence for the Clinical Association between <i>Demodex</i> and Rosacea: A Review

作者：Fen Fen Wei, Li Li, Yi Kong, Xiaofeng Yan, Kevin Varghese, Song Zhang, Jiang Jian, Bao Chai, Hongxiang Chen · 发表于：Dermatology · 年份：2023 · DOI：10.1159/000534245 · 被引用次数：26 · 研究领域：Acne and Rosacea Treatments and Effects、Hidradenitis Suppurativa and Treatments、Dermatological and COVID-19 studies

BACKGROUND: Rosacea is a chronic inflammatory dermatological condition in humans, and its pathogenesis remains unclear. However, the development of rosacea is suspected to be related to Demodex, a microscopic commensal organism that resides in or near hair follicles and sebaceous glands. Although Demodex is known to be a host-specific, obligate commensal organism, it is currently difficult to be cultured in vitro to parasitize and infect other animal hosts. Therefore, direct evidence for a pathogenic role of Demodex in rosacea is currently lacking. SUMMARY: As circumstantial evidence, non-invasive skin-detecting techniques have shown abnormally elevated numbers of Demodex in rosacea patients. Increased cytokine levels such as IL-10, IL-8, and IL-12p70 have been observed in human sebocytes following the Demodex challenge, and acaricides have been found to be effective in rosacea therapy, all point to a close relationship between Demodex and rosacea. Based on these findings, we conducted a comprehensive literature review to summarize the current state of knowledge, research insights, and clinical treatment recommendations for Demodex-associated rosacea, with the ultimate goal of improving patient outcomes.