Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease

作者：Shan Jiang, Hua Su · 发表于：Cell Communication and Signaling · 年份：2023 · DOI：10.1186/s12964-023-01323-w · 被引用次数：26 · 研究领域：Chronic Kidney Disease and Diabetes、Extracellular vesicles in disease、Renal Diseases and Glomerulopathies

Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its pathogenesis. Nonetheless, the cellular crosstalk of podocytes and endothelial cells in DKD is better understood than that of mesangial cells (MCs) and renal tubular epithelial cells (TECs). As the significance of MCs and TECs in DKD pathophysiology has recently become more apparent, we reviewed the existing literature on the cellular crosstalk of MCs and TECs in the context of DKD to acquire a comprehensive understanding of their cellular communication. Insights into the complicated mechanisms underlying the pathophysiology of DKD would improve its early detection, care, and prognosis. Video Abstract.