Three-Component Aminoheteroarylation of Alkenes via Photoinduced EDA Complex Activation

作者：Chengcheng Shi, Lin Guo, Han Gao, Mengqi Luo, Xiao Zhou, Chao Yang, Wujiong Xia · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c02988 · 被引用次数：34 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

A catalyst-free approach for the multicomponent aminoheteroarylation reaction of alkenes with N -aminopyridinium salts and heteroarenes is herein described. The reaction shows good functional group tolerance and allows the generation of valuable β-heteroarylethylamines in satisfying yields. In this transformation, N -aminopyridinium salts and heteroarenes are utilized to generate electron donor–acceptor complexes, which undergo a single-electron transfer process upon light irradiation to form key amidyl radicals and heteroaryl radical cations. The amidyl radical is subsequently captured by alkenes, followed by a Minisci-type reaction to yield the desired β-heteroarylamines as products.