Prior information guided auto-segmentation of clinical target volume of tumor bed in postoperative breast cancer radiotherapy

作者：Xin Xie, Yuchun Song, Ye Feng, Shulian Wang, Hui Yan, Xinming Zhao, Jianrong Dai · 发表于：Radiation Oncology · 年份：2023 · DOI：10.1186/s13014-023-02355-9 · 被引用次数：4 · 研究领域：Advanced Radiotherapy Techniques、AI in cancer detection、Medical Imaging Techniques and Applications

BACKGROUND: Accurate delineation of clinical target volume of tumor bed (CTV-TB) is important but it is also challenging due to surgical effects and soft tissue contrast. Recently a few auto-segmentation methods were developed to improve the process. However, those methods had comparatively low segmentation accuracy. In this study the prior information was introduced to aid auto-segmentation of CTV-TB based on a deep-learning model. METHODS: To aid the delineation of CTV-TB, the tumor contour on preoperative CT was transformed onto postoperative CT via deformable image registration. Both original and transformed tumor contours were used for prior information in training an auto-segmentation model. Then, the CTV-TB contour on postoperative CT was predicted by the model. 110 pairs of preoperative and postoperative CT images were used with a 5-fold cross-validation strategy. The predicted contour was compared with the clinically approved contour for accuracy evaluation using dice similarity coefficient (DSC) and Hausdorff distance. RESULTS: The average DSC of the deep-learning model with prior information was improved than the one without prior information (0.808 vs. 0.734, P < 0.05). The average DSC of the deep-learning model with prior information was higher than that of the traditional method (0.808 vs. 0.622, P < 0.05). CONCLUSIONS: The introduction of prior information in deep-learning model can improve segmentation accuracy of CTV-TB. The proposed method provided an effect...