Highly asymmetric aldol reaction of isatins and ketones catalyzed by chiral bifunctional primary-amine organocatalyst on water

作者：Xiao‐Xiong Lv, Ning Liu, Fei Chen, Hao Zhang, Zhi‐Hong Du, Pei Wang, Yuan Meng, Chao‐Shan Da · 发表于：Organic & Biomolecular Chemistry · 年份：2023 · DOI：10.1039/d3ob01227a · 被引用次数：8 · 研究领域：Asymmetric Synthesis and Catalysis、Asymmetric Hydrogenation and Catalysis、Synthesis and Catalytic Reactions

An efficient asymmetric aldol reaction between isatins and ketones on water has been reported, which afforded a series of enantioenriched 3-hydroxy-2-oxindoles in excellent yields and stereoselectivities under mild conditions.