Tongxinluo capsule in combination with conventional therapies for stable angina pectoris: A meta-analysis and systematic review

作者：Ruli Feng, Qian Lin, Dawei Wei, Li Yan, Rong Zhang, Kaixin Jiang, Yuxuan Li, Long Xie, Junyan Xia, Peixun Zheng, Xiang Ji, Wujiao Wang, Xinyan Qu, Qun Gao, Yi Pan, Jing Liu · 发表于：Medicine · 年份：2023 · DOI：10.1097/md.0000000000035405 · 被引用次数：8 · 研究领域：Lipid metabolism and disorders、Atherosclerosis and Cardiovascular Diseases、Adipokines, Inflammation, and Metabolic Diseases

BACKGROUND: This study aimed to assess the efficacy and safety of Tongxinluo capsule (TXLC) in combination with conventional therapies for treating stable angina pectoris (SAP) through a comprehensive meta-analysis and systematic review. METHODS: We conducted a systematic search of the China National Knowledge Infrastructure, Wanfang, VIP, PubMed, Embase, and CENTRAL databases for randomized controlled trials investigating the use of TXLC as adjuvant therapy for SAP published up to June 2023. The Cochrane Handbook was used to evaluate the risk of bias. Meta-analysis was performed using Review Manager 5.4.1, and publication bias was assessed using Begg test and Egger test in the Stata SE 12.0 software. GRADEpro was used to assess the quality of the evidence. RESULTS: This meta-analysis included 26 randomized controlled trials with a total of 2352 patients. TXLC co-administration demonstrated significant reduction in angina attack frequency (mean difference (MD) -0.91, 95% confidence interval (CI) -0.97 to -0.84, P < .00001) and duration (MD -1.71, 95% CI -2.24 to -1.19, P < .00001), decreased use of nitroglycerin tablets (MD -6.28, 95% CI -7.16 to -5.41, P < .00001), lowered C-reactive protein (MD -1.19, 95% CI -1.35 to -1.03, P < .00001) and low-density lipoprotein cholesterol levels (MD -0.68, 95% CI -0.86 to -0.51, P < .00001). TXLC co-administration did not increase gastrointestinal reactions (RR 1.17, 95% CI 0.38 to 3.57, P = .78). The Begg test and Egger test results ind...