Burden of Respiratory Syncytial Virus–Associated Acute Respiratory Infections During Pregnancy

作者：Sébastien Kenmoe, Helen Y. Chu, Fatimah S. Dawood, Jennifer Milucky, Wanitchaya Kittikraisak, Hamish Matthewson, Durga Kulkarni, Piyarat Suntarattiwong, Collrane Frivold, Sarita Mohanty, Fiona P. Havers, You Li, Harish Nair, PROMISE Investigators, Jeroen Aerssens, Benoît Callendret, Gabriela Ispas, Bahar Ahani, Jessica E. Atwell, Elizabeth Begier, Monica F Turiga, Tin Tin Htar, Mathieu Bangert, Rolf Kramer, Charlotte Vernhes, Philippe Beutels, Louis Bont, Harry Campbell, Harish Nair, You Li, Sébastien Kenmoe, Richard Osei‐Yeboah, Xin Wang, Rachel Cohen, Gaël Dos Santos, Philip Joosten, Theo Last, Veena Kumar, Núria Machín, Hanna Nohynek, Peter Openshaw, John Paget, Andrew J. Pollard, Anne Teirlinck, Arantxa Urchueguía-Fornes, Ainara Mira‐Iglesias, Alejandro Orrico‐Sánchez, Javier Díez‐Domingo, Johannesen Caroline Klint, Mark D. Miller, Rafael Mikolajczyk, Terho Heikkinen · 发表于：The Journal of Infectious Diseases · 年份：2023 · DOI：10.1093/infdis/jiad449 · 被引用次数：22 · 研究领域：Respiratory viral infections research、COVID-19 Impact on Reproduction、COVID-19 Clinical Research Studies

BACKGROUND: With the licensure of maternal respiratory syncytial virus (RSV) vaccines in Europe and the United States, data are needed to better characterize the burden of RSV-associated acute respiratory infections (ARI) in pregnancy. The current study aimed to determine among pregnant individuals the proportion of ARI testing positive for RSV and the RSV incidence rate, RSV-associated hospitalizations, deaths, and perinatal outcomes. METHODS: We conducted a systematic review, following PRISMA 2020 guidelines, using 5 databases (Medline, Embase, Global Health, Web of Science, and Global Index Medicus), and including additional unpublished data. Pregnant individuals with ARI who had respiratory samples tested for RSV were included. We used a random-effects meta-analysis to generate overall proportions and rate estimates across studies. RESULTS: Eleven studies with pregnant individuals recruited between 2010 and 2022 were identified, most of which recruited pregnant individuals in community, inpatient and outpatient settings. Among 8126 pregnant individuals, the proportion with ARI that tested positive for RSV ranged from 0.9% to 10.7%, with a meta-estimate of 3.4% (95% confidence interval [CI], 1.9%-54%). The pooled incidence rate of RSV among pregnant individuals was 26.0 (95% CI, 15.8-36.2) per 1000 person-years. RSV hospitalization rates reported in 2 studies were 2.4 and 3.0 per 1000 person-years. In 5 studies that ascertained RSV-associated deaths among 4708 pregnant ind...