Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

作者：Mahshid Askarizadeh, Nadia Esfandiari, Bizhan Honarvar, Seyed Ali Sajadian, Amin Azdarpour · 发表于：ChemBioEng Reviews · 年份：2023 · DOI：10.1002/cben.202300027 · 被引用次数：303 · 研究领域：Crystallization and Solubility Studies、Drug Solubulity and Delivery Systems、Protein purification and stability

Abstract Proper medication dissolution must be ensured when developing or manufacturing a new solid dosage form. Quantitative analyses performed in dissolution or release tests become simpler when applying mathematical formulae which represent dissolution outcomes as a function of several dosage form properties. Methodologies utilized to examine the kinetics of drug release from controlled‐release formulations are reviewed. The analysis of variance was conducted using statistical, model‐independent, and ‐dependent techniques for the dissolution profile comparison and fitting, respectively. Model equations, including zero‐ and first‐order, Hixson‐Crowell, Weibull, Higuchi, Korsmeyer‐Peppas, Baker‐Lonsdale, Hopfenberg, etc., were employed to match the experimental data. Additional release parameters were taken to illustrate the drug release patterns. Using correlation factors and the Akaike information criterion (AIC), the best‐fitting model was discovered, as were the transport phenomena affecting the behavior of the recognized formulations.