Huperzine alkaloids: forty years of total syntheses

作者：Bichu Cheng, Lili Song, Fen‐Er Chen · 发表于：Natural Product Reports · 年份：2023 · DOI：10.1039/d3np00029j · 被引用次数：12 · 研究领域：Cholinesterase and Neurodegenerative Diseases、Computational Drug Discovery Methods、Chemical synthesis and alkaloids

alkaloids family. The representative member huperzine A has a unique structure and exhibits potent inhibitory activity against acetylcholine esterase (AChE). This subfamily of alkaloids provides a great opportunity for developing synthetic methodologies and asymmetric synthesis. The efforts towards the synthesis of huperzine A have cultivated dozens of total syntheses and a rich body of new chemistry. Impressive progress has also been made in the synthesis of other huperzine alkaloids. The total syntheses of huperzines B, U, O, Q and R, structure reassignment and total syntheses of huperzines K, M and N have been reported in the past decade. This review focuses on the synthetic organic chemistry and the biosynthesis and medicinal chemistry of huperzines are also covered briefly.