Smoking index and COPD duration as potential risk factors for development of osteoporosis in patients with non-small cell lung cancer – A retrospective case control study evaluated by CT Hounsfield unit

作者：Yue Zhou, Yunxiang Hu, Xixi Yan, Yueyue Zheng, Sanmao Liu, Hongmei Yao · 发表于：Heliyon · 年份：2023 · DOI：10.1016/j.heliyon.2023.e20885 · 被引用次数：9 · 研究领域：Medical Imaging Techniques and Applications、Bone health and treatments、Statistical Methods in Epidemiology

Objective To investigate the effect of smoking index (calculated as number of cigarettes per day × smoking years) and chronic obstructive pulmonary disease (COPD) duration on osteoporosis (OP)evaluated by opportunistic chest CT in patients with non-small cell lung cancer (NSCLC). Methods A total of 101 patients diagnosed with NSCLC were included in our cohort study. Among them, 50 patients with a history of smoking and COPD were assigned to the experimental group, while 51 patients without a history of smoking and COPD were assigned to the control group. Hounsfield unit (HU) value was measured by conventional chest CT to investigate the bone mineral density; and the mean values of axial HU value in the upper, middle and lower parts of T4, T7, T10 and L1 vertebral bodies were measured as the study variables. Results There were no significant differences in gender, age, body mass index, type of lung cancer, clinical stage of lung cancer and comorbidities between the two groups (P = 0.938，P = 0.158，P = 0.722,P = 0.596,P = 0.813,P = 0.655). The overall mean HU values of T4, T7, T10, L1 in the experimental group were 116.60 ± 30.67, 110.56 ± 30.03, 109.18 (96.85–122.95), 94.63 (85.20–104.12) and 106.86 ± 22.26, respectively, which were significantly lower than those in the control group (189.55 ± 34.57, 174.54 ± 35.30, 172.73 (156.33–199.50), 158.20 (141.60–179.40) and 177.50 ± 33.49) ( P ＜0.05). And in the experimental group, smoking index and COPD duration were significantly and...